NFAT4 is required for JC virus infection of glial cells.

NFAT4 is required for JC virus infection of glial cells. Research Abstract Details 

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NFAT4 is required for JC virus infection of glial cells. Abstract Text:

Kate Manley,Bethany A O'hara,Gretchen V Gee,Carl P Simkevich,John M Sedivy,Walter J Atwood,

The human polyomavirus JC virus (JCV) infects 70% of the population worldwide. In immunosuppressed patients, JCV infection can lead to progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system (CNS). The majority of PML cases occur in the setting of human immunodeficiency virus (HIV) infection, and it has been suggested that the link between HIV and the development of PML is in part related to the production of numerous cytokines in the CNS during HIV infection. To examine the link between the expression of inflammatory cytokines and JCV infection, we tested an anti-inflammatory compound, cyclosporine A (CsA), for its ability to block JCV infection of glial cells. We found that CsA inhibited JCV infection by preventing the activation of the transcription factor nuclear factor of activated T cells 4 (NFAT4). Luciferase reporter assays and chromatin immunoprecipitation assays revealed that NFAT4 directly bound the JCV promoter during infection and was important for the activation of both early and late transcription. In addition, the expression of the JCV early viral gene products increased NFAT activity to further aid viral transcription. The necessity of NFAT for JCV infection suggests that calcium signaling and the activation of NFAT in glial cells are required for JCV infection of the CNS.

NFAT4 is required for JC virus infection of glial cells. Publishing Authors By Initials

K Manley,BA O'hara,GV Gee,CP Simkevich,JM Sedivy,WJ Atwood,

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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NFAT4 is required for JC virus infection of glial cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 80

Page Numbers: 12079-85

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 11

MONTH: 10

YEAR: 2006

NFAT4 is required for JC virus infection of glial cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

NFAT4 is required for JC virus infection of glial cells. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: metabolism

Chemical & Substance for Abstract: NFAT4 is required for JC virus infection of glial cells. Information

Substance Name: Luciferases

Registry Number: EC 1.13.12.-

Grant and Affiliation Information for NFAT4 is required for JC virus infection of glial cells.

AFFILIATION: Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS43097

ACRONYM: NS

MEDLINETA: J Virol

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