Next-generation sequencing: applications beyond genomes.

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Next-generation sequencing: applications beyond genomes. Abstract Text:

The development of DNA sequencing more than 30 years ago has profoundly impacted biological research. In the last couple of years, remarkable technological innovations have emerged that allow the direct and cost-effective sequencing of complex samples at unprecedented scale and speed. These next-generation technologies make it feasible to sequence not only static genomes, but also entire transcriptomes expressed under different conditions. These and other powerful applications of next-generation sequencing are rapidly revolutionizing the way genomic studies are carried out. Below, we provide a snapshot of these exciting new approaches to understanding the properties and functions of genomes. Given that sequencing-based assays may increasingly supersede microarray-based assays, we also compare and contrast data obtained from these distinct approaches.

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Next-generation sequencing: applications beyond genomes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical Society transactions

VOLUME: 36

Page Numbers: 1091-6

Journal Abbreviation: Biochem. Soc. Trans.

ISSN: 0300-5127

DAY: 16

MONTH: Oct

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Next-generation sequencing: applications beyond genomes.

AFFILIATION: Cancer Research UK, Fission Yeast Functional Genomics Group, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, U.K.

Country: England

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MEDLINETA: Biochem Soc Trans

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