Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae.

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Research Abstract Details 

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Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Abstract Text:

Zhiqiang Du,Kyung-Won Park,Haijing Yu,Qing Fan,Liming Li,

SWI/SNF, an evolutionarily conserved ATP-dependent chromatin-remodeling complex, has an important role in transcriptional regulation. In Saccharomyces cerevisiae, SWI/SNF regulates the expression of approximately 6% of total genes through activation or repression. Swi1, a subunit of SWI/SNF, contains an N-terminal region rich in glutamine and asparagine, a notable feature shared by all characterized yeast prions--a group of unique proteins capable of self-perpetuating changes in conformation and function. Here we provide evidence that Swi1 can become a prion, [SWI+]. Swi1 aggregates in [SWI+] cells but not in nonprion cells. Cells bearing [SWI+] show a partial loss-of-function phenotype of SWI/SNF. [SW+] can be eliminated by guanidine hydrochloride treatment, HSP104 deletion or loss of Swi1. Moreover, we show [SWI+] is dominantly and cytoplasmically transmitted. Our findings reveal a novel mechanism of 'protein-only' inheritance that results in modification of chromatin-remodeling and, ultimately, global gene regulation.

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Publishing Authors By Initials

Z Du,KW Park,H Yu,Q Fan,L Li,

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Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature genetics

VOLUME: 40

Page Numbers: 460-5

Journal Abbreviation: Nat. Genet.

ISSN: 1546-1718

DAY: 23

MONTH: 03

YEAR: 2008

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Information

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LANGUAGE: eng

NlmUniqueID: 9216904

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Grant and Affiliation Information for Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae.

AFFILIATION: Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, Searle 5-474, 320 East Superior Street, Chicago, Illinois 60611, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01NS056086

ACRONYM: NS

MEDLINETA: Nat Genet

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