New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).

New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Research Abstract Details 

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New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Abstract Text:

Hailong Zhang,Hisashi Matsuda,Akira Kumahara,Yuki Ito,Seikou Nakamura,Masayuki Yoshikawa,

Two 3-phenyldihydroisocoumarins (hydrangenol and phyllodulcin), a 3-phenylisocoumarin (thunberginol A), and a stilbene (hydrangeaic acid) from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium) promoted adipogenesis of 3T3-L1 cells. Hydrangenol, a principal constituent, significantly increased the amount of adiponectin released into the medium and mRNA levels of adiponectin, peroxisome proliferator-activated receptor gamma2 (PPARgamma2), and glucose transporter 4 (GLUT4), while it decreased the expression of interleukin 6 (IL-6) mRNA. Furthermore, hydrangenol significantly lowered blood glucose and free fatty acid levels 2 weeks after its administration at a dose of 200 mg/kg/d in KK-A(y) mice.

New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Publishing Authors By Initials

H Zhang,H Matsuda,A Kumahara,Y Ito,S Nakamura,M Yoshikawa,

For similar plants: plant components: plant components, aerial: plant leaves research abstracts see: plants: plant components: plant components, aerial: plant leaves research

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New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 4972-6

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 10

MONTH: 06

YEAR: 2007

New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Information

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LANGUAGE: eng

NlmUniqueID: 9107377

New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Keywords Mesh Terms:

KEYWORDS: Plant Leaves

MESH TERMS: metabolism

Chemical & Substance for Abstract: New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Information

Substance Name: phyllodulcin

Registry Number: 480-46-6

Grant and Affiliation Information for New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).

AFFILIATION: Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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