New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy.

New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Research Abstract Details 

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New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Abstract Text:

Huy M Phan,Mei Hua Gao,N Chin Lai,Tong Tang,H Kirk Hammond,Huy M Phan,Mei Hua Gao,N Chin Lai,Tong Tang,H Kirk Hammond,

Congestive heart failure (CHF) affects more than five million people in the United States and results in considerable morbidity, mortality, and economic costs. Patients with class III and IV CHF have a 40% to 50% probability of dying 5 years after symptom onset despite optimal therapy, a prognosis worse than many cancers. A variety of drugs and devices have improved survival-the 50% survival time in 1980 was just 18 months-but the outlook for patients remains dismal and the prevalence of CHF continues to increase. This unmet medical need underscores the importance of developing new approaches for the treatment of CHF. This brief review focuses on data from preclinical experiments regarding the effects of increased adenylyl cyclase type 6 (AC6) expression on cellular and cardiac function, and possible mechanisms for the unexpected favorable effects of increased AC6 content on the failing heart.

New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Publishing Authors By Initials

HM Phan,MH Gao,NC Lai,T Tang,HK Hammond,HM Phan,MH Gao,NC Lai,T Tang,HK Hammond,

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New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Trends in cardiovascular medicine

VOLUME: 17

Page Numbers: 215-21

Journal Abbreviation: Trends Cardiovasc. Med.

ISSN: 1050-1738

DAY: 15

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9108337

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Grant and Affiliation Information for New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy.

AFFILIATION: Department of Medicine, University of California at San Diego, CA 92093, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL081741

ACRONYM: HL

MEDLINETA: Trends Cardiovasc Med

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