New prognostic markers in chronic lymphocytic leukemia.

New prognostic markers in chronic lymphocytic leukemia. Research Abstract Details 

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New prognostic markers in chronic lymphocytic leukemia. Abstract Text:

The prognosis of patients with chronic lymphocytic leukemia (CLL) is extremely variable. Prognostication of patients with CLL has been classically based on clinical parameters. In the last few years, several biologic markers such as cytogenetics, IgVH mutations, CD38 and ZAP-70 expression in leukemic cells have shown to offer important prognostic information. However, before being incorporated into daily practice these markers require standardization and validation in prospective trials. Meanwhile, prognosis of patients with CLL should remain to be based on clinical stages and other easily obtainable clinical parameters. An important area of research is the identification of markers useful for predicting response to therapy. Among them, 17p- reflecting p53 abnormalities is particularly important. Also relevant is 11q- pointing out to ATM defects. The correlation of IgVH mutations, ZAP-70 and CD38 expression with response is unclear and needs further investigation. Finally, there is increasing evidence that response to therapy, particularly when all measurable disease is eradicated, is associated with longer survival.

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New prognostic markers in chronic lymphocytic leukemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood reviews

VOLUME: 22

Page Numbers: 211-9

Journal Abbreviation: Blood Rev.

ISSN: 0268-960X

DAY: 29

MONTH: 04

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 8708558

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AFFILIATION: Institute of Hematology and Oncology, Department of Hematology, Hospital Clínic, IDIBAPS, University of Barcelona.

Country: Scotland

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MEDLINETA: Blood Rev

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