New polyphenols active on beta-amyloid aggregation.

New polyphenols active on beta-amyloid aggregation. Research Abstract Details 

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New polyphenols active on beta-amyloid aggregation. Abstract Text:

,Tristan Richard,Xavier Vitrac,Jean-Michel ,Josep Valls,Jean-Pierre Monti, ,Tristan Richard,Xavier Vitrac,Jean-Michel ,Josep Valls,Jean-Pierre Monti,

New polyphenol classes have been tested against amyloid-beta peptide aggregation. We have identified four novel polyphenols which could be efficient fibril inhibitors in Alzheimer's disease: malvidin and its glucoside and curculigosides B and D. We suggest that molecules with the particular C(6)-linkers-C(6) structure could be potent inhibitors. From the results reported for the flavan-3-ol family, their anti-amyloidogenic effects against whole peptides (1-40 and 1-42) could involve several binding sites.

New polyphenols active on beta-amyloid aggregation. Publishing Authors By Initials

C ,T Richard,X Vitrac,JM ,J Valls,JP Monti,C ,T Richard,X Vitrac,JM ,J Valls,JP Monti,

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New polyphenols active on beta-amyloid aggregation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 828-31

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 17

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9107377

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AFFILIATION: Laboratoire de physique et biophysique, Institut des Sciences de la Vigne et du Vin, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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