New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function.

New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function. Research Abstract Details 

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New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function. Abstract Text:

Xue-Hua Zhang,Hua Chen,Chung-Wah Siu,Kai-Hang Yiu,Wing-Sze Chan,Kathy L Lee,Hon-Wah Chan,Stephen W Lee,Guo-Sheng Fu,Chu-Pak Lau,Hung-Fat Tse,

INTRODUCTION: Emerging data have suggested that right ventricular (RV) apical pacing results in progressive left ventricular (LV) dysfunction and contributes to the development of heart failure (HF). This study aimed to investigate the prevalence and clinical predictors for the development of new-onset HF after long-term RV apical pacing in patients with acquired atrioventricular (AV) block who require permanent pacing. METHODS: We studied the clinical outcomes after long-term RV apical pacing for acquired AV block in 304 patients without a prior history of HF. All patients had >90% ventricular pacing as determined by device diagnostic data. RESULTS: After a median follow-up of 7.8 years, 79 patients (26.0%) developed new-onset HF after RV apical pacing. Univariate Cox-regression analysis revealed that older age at the time of pacemaker implantation (P < 0.001), the presence of coronary artery disease (CAD) (P < 0.001) or atrial fibrillation (P = 0.03), VVI pacemaker (P < 0.001), wider paced QRS duration (P < 0.001), and new-onset myocardial infarction (P < 0.001) were predictors for HF. Multivariate analysis revealed that older age at implantation (Hazard ratio [HR] 1.06, 95% confidential interval [CI] 1.04-1.09, P < 0.001), CAD (HR 1.98, 95% CI 1.12-3.50, P < 0.05), and a wider paced QRS duration (HR 1.27 for each 10 ms increment, 95% CI 1.11-1.45, P = 0.001) were independent predictors of HF. Furthermore, cardiovascular mortality was significantly increased in those with HF (36.7% vs. 2.7%, P < 0.001). CONCLUSIONS: After a median follow-up of 7.8 years, permanent RV apical pacing was associated with HF in 26% of patients. Elderly age at the time of implant, a wider paced QRS duration and the presence of CAD independently predicted new-onset HF. More importantly, HF after RV apical pacing was associated with a higher cardiovascular mortality.

New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function. Publishing Authors By Initials

XH Zhang,H Chen,CW Siu,KH Yiu,WS Chan,KL Lee,HW Chan,SW Lee,GS Fu,CP Lau,HF Tse,

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New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cardiovascular electrophysiology

VOLUME: 19

Page Numbers: 136-41

Journal Abbreviation: J. Cardiovasc. Electrophysiol.

ISSN: 1540-8167

DAY: 12

MONTH: 11

YEAR: 2007

New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function. Information

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LANGUAGE: eng

NlmUniqueID: 9010756

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Grant and Affiliation Information for New-onset heart failure after permanent right ventricular apical pacing in patients with acquired high-grade atrioventricular block and normal left ventricular function.

AFFILIATION: Cardiology Division, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Hong Kong, China.

Country: United States

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MEDLINETA: J Cardiovasc Electrophysiol

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