New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma.

New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Abstract Text:

Cui Shuangjin,Feng Fang,Liu Han,Ma Ming,

A novel precolumn derivatization method is described for the quantitative determination of amantadine, rimantadine and memantine in biological samples by HPLC with UV detection. The derivatization was performed at room temperature using anthraquinone-2-sulfonyl chloride (ASC) as reagent for only 10 min and without postderivatization treatment to inactivate excess reagent. The derivatives were analyzed by isocratic HPLC with a UV detector at 256 nm on a Lichrosper C18 column. The linear range for the determination of three drugs spiked in plasma (0.2 ml) was 0.05-5.0 microg/ml for amantadine and rimantadine, 0.05-2.0 microg/ml for memantine, respectively. The limits of detection and quantification were 20 and 50 ng/ml for the analytes, respectively. Application of the method to the analysis of amantadine, rimantadine and memantine in rat plasma and pharmacokinetic studies are demonstrated and proved feasible.

New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Publishing Authors By Initials

C Shuangjin,F Fang,L Han,M Ming,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

PUBMED ID PMID:

MEDLINE DATE:

New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 44

Page Numbers: 1100-5

Journal Abbreviation:

ISSN: 0731-7085

DAY: 24

MONTH: 04

YEAR: 2007

New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309336

New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: chemistry

Chemical & Substance for Abstract: New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Information

Substance Name: Amantadine

Registry Number: 768-94-5

Grant and Affiliation Information for New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma.

AFFILIATION: Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pharm Biomed Anal

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma Related Publications

• A "moonlighting" dizinc aminopeptidase from Streptomyces griseus: mechanisms for peptide hydrolysis and the 4 x 10(10)-fold acceleration of the alternative phosphodiester hydrolysis.
• Catechol oxidase activity of di-Cu2+-substituted aminopeptidase from Streptomyces griseus.
• Compound salvia droplet pill, a traditional Chinese medicine, for the treatment of unstable angina pectoris: A systematic review.
• Construction of a sequence-tagged high-density genetic map of papaya for comparative structural and evolutionary genomics in brassicales.
• Crucial effects of coupling coefficients on quasi-phase-matched harmonic generation in an optical superlattice.
• Crucial effects of coupling coefficients on quasi-phase-matched harmonic generation in an optical superlattice: errata.
• Effect of interleukin-1beta on I(A) and I(K) currents in cultured murine trigeminal ganglion neurons.
• Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety.
• Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity.
• Investment in body image among patients diagnosed with or at risk for malignant melanoma.
• Low X/Y divergence in four pairs of papaya sex-linked genes.
• Methodology and reporting quality of systematic review/meta-analysis of traditional Chinese medicine.
• New Hepatoprotective Triterpenes form Canarium album.
• New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma.
• P47.09: Late abortion for fetal anomalies: ten case experiences in one tertiary center in Taiwan and report of a novel method (fetal cardiac tamponade).
• Second-harmonic generation in quasi-periodically domain-inverted Sr(0.6) Ba(0.4) Nb(2)O(6) optical superlattices.
• TGIF, a gene associated with human brain defects, regulates neuronal development.
• The Influence of Dynamic Trans-tibial Prosthetic Alignment on Standing Plantar Foot Pressure.
• Third-harmonic generation in a general two-component quasi-periodic optical superlattice.
• Tissue differential expression of lycopene beta-cyclase gene in papaya.
• [Alteration in serum cytokines of patients with multiple organ dysfunction syndrome after liver transplantation]
• [Assessment and nursing care of patients in acute confusion in intensive care units.]
• [Management of nutritional support and stress hyperglycemia after orthotopic liver transplantation]
• [Research on the progress of neuroprosthesis for the limb motor system]
• [SPG3A-hereditary spastin paraplegia with genetic anticipation and incomplete penetrance]
• [Study on spectrophotometric determination of trace nitrite with brilliant cresol blue]
• [Study on the hepatoxicity mechanisms of huangyaozi (Rhizoma dioscoreae bulbiferae) on mouse liver by cDNA microarray]
• [Trachoma in Singapore]
• [Treatment of complex acetabular fractures by a modified extended iliofemoral approach]
• [Treatment of mandibular retrusion patients with Forsus appliance following growth spurts]