New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents.

New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents. Research Abstract Details 

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New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents. Abstract Text:

Girish K Rawal,Amit Kumar,Urmila Tawar,Yashwant D Vankar,Girish K Rawal,Amit Kumar,Urmila Tawar,Yashwant D Vankar,Girish K Rawal,Amit Kumar,Urmila Tawar,Yashwant D Vankar,

Chloroamidation of olefins using a new reagent system (COCl)2-AgNO3-CH3CN was observed. Various glycals with this reagent system produce 2-chloro-1-acetamido sugars in good yields which, in turn, were converted to free amino derivatives and various glycopeptides. The acetamido sugar derivatives and free amines were found to be promising anticancer agents against the U-87 malignant glyoma (a brain tumor) cell line with IC-50 = 1 nm-22 muM, and they were found to be far less cytotoxic against a normal human embryonic kidney cell line.

New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents. Publishing Authors By Initials

GK Rawal,A Kumar,U Tawar,YD Vankar,GK Rawal,A Kumar,U Tawar,YD Vankar,GK Rawal,A Kumar,U Tawar,YD Vankar,

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New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic letters

VOLUME: 9

Page Numbers: 5171-4

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 10

MONTH: 11

YEAR: 2007

New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents. Information

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LANGUAGE: eng

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Grant and Affiliation Information for New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents.

AFFILIATION: Department of Chemistry, Indian Institute of Technology, Kanpur-208016, India and Ambedkar Centre for Biomedical Research, University of Delhi, Delhi-110007, India.

Country: United States

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MEDLINETA: Org Lett

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