New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure.

New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Research Abstract Details 

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New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Abstract Text:

Andrew A Strasser,Caryn Lerman,Paul M Sanborn,Wallace B Pickworth,Eric A Feldman,

Potential reduced exposure products (PREPs) are marketed as a means to reduce exposure to tobacco toxicants. Quest cigarettes, a new type of PREP, use genetically modified tobacco to provide a nicotine step-down approach, and are available as 0.6, 0.3 and 0.05 mg nicotine cigarettes. However, these cigarettes deliver equivalent levels of tar (10 mg). Prior research on low nicotine cigarettes suggests smokers will compensate for lower nicotine delivery by increasing their puffing behavior to extract more nicotine. This study tested the hypothesis that compensatory smoking will occur with this PREP as nicotine levels decrease, increasing exposure to tobacco toxins. Fifty smokers completed a within-subject human laboratory study investigating the effect of cigarette nicotine level on smoking behavior. Cigarette nicotine level was double-blinded and order of presentation counter-balanced. Breath carbon monoxide (CO) boost was used as a biomarker of smoke exposure; total puff volume to assess smoking behavior. Total puff volume was greatest for the 0.05 mg nicotine cigarette and CO boost was moderately greater after smoking the 0.3 and 0.05 mg cigarettes compared to the 0.6 mg nicotine cigarette. These data provide novel behavioral and biochemical evidence of compensatory smoking when smoking lower nicotine cigarettes. Although marketed as a PREP, increases in CO boost suggest this product can potentially be a harm-increasing product.

New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Publishing Authors By Initials

AA Strasser,C Lerman,PM Sanborn,WB Pickworth,EA Feldman,

For similar behavior and behavior mechanisms: behavior: habits: smoking research abstracts see: behavior and behavior mechanisms: behavior: habits: smoking research

PUBMED ID PMID:

MEDLINE DATE:

New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Drug and alcohol dependence

VOLUME: 86

Page Numbers: 294-300

Journal Abbreviation:

ISSN: 0376-8716

DAY: 22

MONTH: 08

YEAR: 2006

New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7513587

New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Keywords Mesh Terms:

KEYWORDS: Smoking

MESH TERMS: psychology

Chemical & Substance for Abstract: New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Information

Substance Name: Carbon Monoxide

Registry Number: 630-08-0

Grant and Affiliation Information for New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure.

AFFILIATION: Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States. strasse3@mail.med.upenn.edu

Country: Ireland

AGENCY: United States PHS

GRANT: P5084718

ACRONYM:

MEDLINETA: Drug Alcohol Depend

REFSOURCE:

DATABASENAME:

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Number Hits: 0

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