New insights into the structures and functions of human monoamine oxidases A and B.

New insights into the structures and functions of human monoamine oxidases A and B. Research Abstract Details 

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New insights into the structures and functions of human monoamine oxidases A and B. Abstract Text:

D E Edmondson,L DeColibus,C Binda,M Li,A Mattevi,

Structural studies on recombinant human monoamine oxidase A (hMAO-A) provides interesting insights on comparison with that determined for human MAO-B (hMAO-B) as well as comparison with that previously published for rat MAO-A. The active site cavity of hMAO-A is monopartite (as with rat MAO-A) while hMAO-B is a bipartite cavity. hMAO-A crystallizes as a monomeric form, in contrast to the dimeric forms exhibited by hMAO-B and rat MAO-A. All of the known MAO structures show nearly identical geometries around the covalent FAD sites. Differences in active site cavity structures occur away from the FAD site through conformational alterations (MAO-A's) and by changes in amino acid residues (hMAO-A and hMAO-B). Differences observed between human and rat MAO-A's raise questions regarding the appropriateness of the rat model in the development of MAO-A specific inhibitors as drugs for eventual human use.

New insights into the structures and functions of human monoamine oxidases A and B. Publishing Authors By Initials

DE Edmondson,L DeColibus,C Binda,M Li,A Mattevi,

For similar biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research

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New insights into the structures and functions of human monoamine oxidases A and B. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neural transmission (Vienna, Austria :

VOLUME: 114

Page Numbers: 703-5

Journal Abbreviation:

ISSN: 0300-9564

DAY: 29

MONTH: 03

YEAR: 2007

New insights into the structures and functions of human monoamine oxidases A and B. Information

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LANGUAGE: eng

NlmUniqueID: 9702341

New insights into the structures and functions of human monoamine oxidases A and B. Keywords Mesh Terms:

KEYWORDS: Species Specificity

MESH TERMS: metabolism

Chemical & Substance for Abstract: New insights into the structures and functions of human monoamine oxidases A and B. Information

Substance Name: Monoamine Oxidase

Registry Number: EC 1.4.3.4

Grant and Affiliation Information for New insights into the structures and functions of human monoamine oxidases A and B.

AFFILIATION: Department of Biochemistry and Chemistry, Emory University, Atlanta, GA 30322, USA. deedmon@emory.edu

Country: Austria

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MEDLINETA: J Neural Transm

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