New insights into mitotic chromosome condensation: a role for the prolyl isomerase pin1.

New insights into mitotic chromosome condensation: a role for the prolyl isomerase pin1. Research Abstract Details 

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New insights into mitotic chromosome condensation: a role for the prolyl isomerase pin1. Abstract Text:

Yu-Xin Xu,James L Manley,Yu-Xin Xu,James L Manley,

Topoisomerase (Topo) IIalpha and condensin are essential for formation of mitotic chromosomes. However, the mechanism by which these two major components assemble during the chromosome condensation process had been unclear. Recent studies have revealed a coordinated and cooperative process, by which TopoIIalpha functions early to form an axis scaffold, whereas condensin complexes assemble at a later stage critical for chromosome integrity and subsequent segregation. Extending these observations, we recently found that the phosphorylation-dependent prolyl isomerase Pin1 is directly linked to the process. This conclusion is based on the observation of strong and extensive interactions of Pin1 with chromatin specifically at G(2)/M phase. Pin1 modulates the mitotic phosphorylation of TopoIIalpha by cdc2/cyclinB and promotes the association of phosphorylated TopoIIalpha with DNA elements to form an axis scaffold complex. The evidence highlights a critical role of Pin1 via its regulation of mitotic phosphorylation of key components in the chromosome condensation process.

New insights into mitotic chromosome condensation: a role for the prolyl isomerase pin1. Publishing Authors By Initials

YX Xu,JL Manley,YX Xu,JL Manley,

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New insights into mitotic chromosome condensation: a role for the prolyl isomerase pin1. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 6

Page Numbers: 2896-901

Journal Abbreviation: Cell Cycle

ISSN: 1551-4005

DAY: 29

MONTH: 08

YEAR: 2007

New insights into mitotic chromosome condensation: a role for the prolyl isomerase pin1. Information

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LANGUAGE: eng

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AFFILIATION: Department of Biological Sciences, Columbia University, New York, New York, USA.

Country: United States

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MEDLINETA: Cell Cycle

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