New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9.

New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9. Research Abstract Details 

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New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9. Abstract Text:

Wenpeng Dong,Dakuan Gao,Hong Lin,Xiang Zhang,Nanlin Li,Fanfan Li,Wenpeng Dong,Dakuan Gao,Hong Lin,Xiang Zhang,Nanlin Li,Fanfan Li,

Resveratrol, a natural polyphenolic compound, is found in a few edible materials and is well known for its phytoestrogenic and antioxidant properties. A growing body of in vivo and in vitro evidence indicates that resveratrol has protective effect on cerebral ischemic stroke. Here, we review the effect of resveratrol on cerebral ischemic stroke, and propose a possible mechanism. During acute phases after stroke, resveratrol preconditioning suppresses matrix metalloprotease-9 activity to ameliorate blood-brain barrier disruption, edema formation and neuronal cell death caused by ischemia and reperfusion. But during delayed phases after stroke, resveratrol preconditioning conduces to cerebral angiogenesis and brain regeneration through increasing matrix metalloprotease-9 activity and expression. Resveratrol's effect on matrix metalloprotease-9 is distinguishing in different phases because of temporal and spatial redistribution of matrix metalloprotease-9 within the cells of the neurovascular unit after cerebral ischemia. This paper also hypothesizes that resveratrol treatment after cerebral ischemia might be beneficial for cerebral angiogenesis and brain regeneration during delayed phases after stroke.

New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9. Publishing Authors By Initials

W Dong,D Gao,H Lin,X Zhang,N Li,F Li,W Dong,D Gao,H Lin,X Zhang,N Li,F Li,

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New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Medical hypotheses

VOLUME: 70

Page Numbers: 52-5

Journal Abbreviation: Med. Hypotheses

ISSN: 0306-9877

DAY: 29

MONTH: 06

YEAR: 2007

New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9. Information

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LANGUAGE: eng

NlmUniqueID: 7505668

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Grant and Affiliation Information for New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9.

AFFILIATION: Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Chang Le West Street, No. 15, Xi'an, Shaanxi Province 710032, PR China.

Country: Scotland

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MEDLINETA: Med Hypotheses

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