New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry.

New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry. Research Abstract Details 

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New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry. Abstract Text:

Paul N Reynolds,David T Curiel,

New generation adenoviral vectors improve gene transfer by car-independent cell entry. Adenoviral (Ad) vectors possess many attributes that have lead to their use as gene delivery agents in human clinical trials. However, gene transfer efficiency has generally been less than that needed for meaningful clinical responses. The restricted tropism of the virus for its native receptor, the coxsackie and adenoviral receptor (CAR), is emerging as a key limitation to the use of these agents. By developing strategies to achieve Ad infection via alternate receptor pathways, enhanced and more specific gene delivery can be achieved. This new generation of tropism-modified agents holds promise for the improved clinical utility of Ad vectors for gene therapy.

New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry. Publishing Authors By Initials

PN Reynolds,DT Curiel,

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New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Kidney international

VOLUME: 61

Page Numbers: 24-31

Journal Abbreviation: Kidney Int.

ISSN: 0085-2538

DAY: 13

MONTH: Jan

YEAR: 2002

New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry. Information

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LANGUAGE: eng

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Grant and Affiliation Information for New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry.

AFFILIATION: Division of Human Gene Therapy, Departments of Medicine, Pathology, and Surgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Country: United States

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MEDLINETA: Kidney Int

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