New findings from non-linear longitudinal modelling of menopausal hormone changes.

New findings from non-linear longitudinal modelling of menopausal hormone changes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

New findings from non-linear longitudinal modelling of menopausal hormone changes. Abstract Text:

Lorraine Dennerstein,Philippe Lehert,Henry G Burger,Janet R Guthrie,Lorraine Dennerstein,Philippe Lehert,Henry G Burger,Janet R Guthrie,Lorraine Dennerstein,Philippe Lehert,Henry G Burger,Janet R Guthrie,

Changes in FSH and estradiol (E(2)) across the menopausal transition are clearly not linear. The present study utilizes data from 204 women who completed the 13-year prospective Melbourne Women's Midlife Health Project. E(2), FSH, symptoms, self-rated health, mood, sexual function and coronary heart disease (CHD) risk were measured longitudinally. We presumed an s-shaped curve for each hormone and estimated five parameters for each hormone curve for each woman: baseline, final value, range, slope at inflexion point and age at inflexion point. These parameters were found to adequately estimate the curve for each hormone. The median age of transition observed for E(2) occurs >1 year later than the median age of transition observed for FSH. FSH parameters did not affect any of the health outcomes analysed. Hot flushes, night sweats, sleeping problems, vaginal dryness and to a lesser extent self-rated health were highly significantly associated with E(2) range and slope. Sexual response and CHD risk were highly significantly associated with final E(2) level (post-menopausally). These findings have clinical relevance in identifying which symptoms will be triggered by steep transitions of E(2) such as sudden withdrawal and which health parameters may require a maintenance level of E(2).

New findings from non-linear longitudinal modelling of menopausal hormone changes. Publishing Authors By Initials

L Dennerstein,P Lehert,HG Burger,JR Guthrie,L Dennerstein,P Lehert,HG Burger,JR Guthrie,L Dennerstein,P Lehert,HG Burger,JR Guthrie,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

New findings from non-linear longitudinal modelling of menopausal hormone changes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Human reproduction update

VOLUME: 13

Page Numbers: 551-7

Journal Abbreviation: Hum. Reprod. Update

ISSN: 1355-4786

DAY: 6

MONTH: 07

YEAR: 2007

New findings from non-linear longitudinal modelling of menopausal hormone changes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9507614

New findings from non-linear longitudinal modelling of menopausal hormone changes. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: New findings from non-linear longitudinal modelling of menopausal hormone changes. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for New findings from non-linear longitudinal modelling of menopausal hormone changes.

AFFILIATION: Office for Gender and Health, Department of Psychiatry, Royal Melbourne Hospital Melbourne, The University of Melbourne, Victoria 3050, Australia.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hum Reprod Update

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

New findings from non-linear longitudinal modelling of menopausal hormone changes Related Publications

• A case study of the South Puget Intertribal Planning Agency's comprehensive cancer control planning and community mobilization process.
• A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex.
• An inconvenient truth: the cumulative influence of childhood poverty on health across the lifespan.
• Clinical problems in syphilis.
• Cognitive recovery in socially deprived young children: the bucharest early intervention project.
• Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects.
• Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts.
• Impaired specific autobiographical memory as a risk factor for posttraumatic stress after trauma.
• Isolation of brucella from apparently healthy individuals.
• Maladaptive self-appraisals before trauma exposure predict posttraumatic stress disorder.
• Molecular epidemiology of the African horse sickness virus S10 gene.
• Neurotrophic factors: are they axon guidance molecules?
• New findings from non-linear longitudinal modelling of menopausal hormone changes.
• Nutrition services and foods and beverages available at school: results from the School Health Policies and Programs Study 2006.
• Prevalence and correlates of illicit methylphenidate use among 8th, 10th, and 12th grade students in the United States, 2001.
• Radiotherapy in poor risk patients with stage I cancer of the endometrium: results of not giving external beam radiotherapy.
• Relation of emotion-related regulation to children's social competence: a longitudinal study.
• Relative abundance and prevalence of selected Borrelia infections in Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) from publicly owned lands in Monmouth County, New Jersey.
• Response of olfactory axons to loss of synaptic targets in the adult mouse.
• Studies of a purine-requiring mutant strain of Escherichia coli.
• Talking straight about emergency contraception.
• The UK Advanced Training Course in Liaison Psychiatry: A 13-year review.
• The relationship of the milking machine to mastitis.
• The rise and progress of medical education in Scotland.
• The use of aminized and phosphorylated cotton fabrics as ion exchange materials in the preparation of oil seed proteins.
• Toxic sublingual goiter.
• Utility of morbidity and mortality conference in end-of-life education in the neonatal intensive care unit.
• Vaginitis emphysematosa associated with an abnormal Pap smear.
• [Not Available.]
• [RECENT PROGRESS IN THE CAMPAIGN AGAINST CHRONIC DISEASE.]