New chemotherapeutic strategies in colorectal cancer.

New chemotherapeutic strategies in colorectal cancer. Research Abstract Details 

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New chemotherapeutic strategies in colorectal cancer. Abstract Text:

Markus Moehler,Andreas Teufel,Peter R Galle,

Since colorectal cancer is the second most prevalent cancer worldwide, its treatment remains a major challenge for researchers, gastroenterologists and oncologists. Despite curative resections, half of all patients diagnosed with colorectal cancer die because of their underlying disease. Integral chemotherapeutic components of standard regimens are 5-fluorouracil (5-FU), its modulation by folinic acid and irinotecan or oxaliplatin. All these drugs sequentially given have results in terms of median overall survival of more than 20 months in the palliative treatment of advanced colorectal cancer. Oral fluoropyrimidines, currently under clinical investigation, are likely to substitute continuous 5-FU. Inhibitors of growth factor receptors or their signaling may further prolong disease-free and overall survival rates. Preliminary evidence exists that improved adjuvant and neoadjuvant chemotherapy strategies may further improve the prognosis, mainly because more patients are able to go for primary or secondary surgery with curative intent.

New chemotherapeutic strategies in colorectal cancer. Publishing Authors By Initials

M Moehler,A Teufel,PR Galle,

For similar pharmaceutical preparations: prodrugs research abstracts see: pharmaceutical preparations: prodrugs research

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New chemotherapeutic strategies in colorectal cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 165

Page Numbers: 250-9

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 2005

New chemotherapeutic strategies in colorectal cancer. Information

Number of References: 48

LANGUAGE: eng

NlmUniqueID: 44671

New chemotherapeutic strategies in colorectal cancer. Keywords Mesh Terms:

KEYWORDS: Prodrugs

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: New chemotherapeutic strategies in colorectal cancer. Information

Substance Name: Camptothecin

Registry Number: 7689-03-4

Grant and Affiliation Information for New chemotherapeutic strategies in colorectal cancer.

AFFILIATION: Department of Internal Medicine, Johannes-Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany. moehler@mail.uni-mainz.de

Country: Germany

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MEDLINETA: Recent Results Cancer Res

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