New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA.

New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. Research Abstract Details 

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New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. Abstract Text:

Dorota Piekna-Przybylska,Wayne A Decatur,Maurille J Fournier,

This report presents a valuable new bioinformatics package for research on rRNA nucleotide modifications in the ribosome, especially those created by small nucleolar RNA:protein complexes (snoRNPs). The interactive service, which is not available elsewhere, enables a user to visualize the positions of pseudouridines, 2'-O-methylations, and base methylations in three-dimensional space in the ribosome and also in linear and secondary structure formats of ribosomal RNA. Our tools provide additional perspective on where the modifications occur relative to functional regions within the rRNA and relative to other nearby modifications. This package of new tools is presented as a major enhancement of an existing but significantly upgraded yeast snoRNA database available publicly at http://people.biochem.umass.edu/sfournier/fournierlab/snornadb/. The other key features of the enhanced database include details of the base pairing of snoRNAs with target RNAs, genomic organization of the yeast snoRNA genes, and information on corresponding snoRNAs and modifications in other model organisms.

New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. Publishing Authors By Initials

D Piekna-Przybylska,WA Decatur,MJ Fournier,

For similar information science: computing methodologies: software research abstracts see: information science: computing methodologies: software research

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New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: RNA (New York, N.Y.)

VOLUME: 13

Page Numbers: 305-12

Journal Abbreviation: RNA

ISSN: 1355-8382

DAY: 5

MONTH: 02

YEAR: 2007

New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9509184

New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. Keywords Mesh Terms:

KEYWORDS: Software

MESH TERMS: methods

Chemical & Substance for Abstract: New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. Information

Substance Name: Saccharomyces cerevisiae Proteins

Registry Number: 0

Grant and Affiliation Information for New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA.

AFFILIATION: Department of biochemistry and Molecular Biology, University of Massachusetts, Amherst 01003, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM19351

ACRONYM: GM

MEDLINETA: RNA

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