New aspects of g-protein-coupled receptor signalling and regulation.

New aspects of g-protein-coupled receptor signalling and regulation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

New aspects of g-protein-coupled receptor signalling and regulation. Abstract Text:

Research on the structure, regulation and signalling properties of the family of seven-transmembrane-helix, heterotrimeric guanine nucleotide-binding protein (G-protein)-coupled receptors (GPCRs) continues at a frantic pace. This reflects their central role in transmission of hormone- and neurotransmitter-encoded information across the plasma membrane of cells. The location of the ligand-binding sites on the extracellular face of the membrane has made them obvious targets for therapeutic intervention in a wide range of conditions resulting from endocrine imbalance. Furthermore, based on the identification of many novel GPCR sequences emerging from expressed sequence tags (ESTs) and other DNA sequencing programmes, it has become clear that the GPCR family is likely to be considerably larger than appreciated in even the recent past. Although neither the natural ligands nor synthetic pharmaceuticals have yet been identified for these so-called ;orphan' GPCRs, they offer the potential for a plethora of new therapeutic targets. Within a short review, it is impossible to cover all the current developments in this field and the topics selected represent a personal view of recent highlights of areas that provide both novel and general insights into the function and regulation of GPCRs.

New aspects of g-protein-coupled receptor signalling and regulation. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

New aspects of g-protein-coupled receptor signalling and regulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Trends in endocrinology and metabolism: TEM

VOLUME: 9

Page Numbers: 13-9

Journal Abbreviation: Trends Endocrinol. Metab.

ISSN: 1043-2760

DAY: 14

MONTH: 04

YEAR: 2008

New aspects of g-protein-coupled receptor signalling and regulation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9001516

New aspects of g-protein-coupled receptor signalling and regulation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: New aspects of g-protein-coupled receptor signalling and regulation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for New aspects of g-protein-coupled receptor signalling and regulation.

AFFILIATION: Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow UK G12 8QQ.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Trends Endocrinol Metab

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

New aspects of g-protein-coupled receptor signalling and regulation Related Publications

• A simple approach to test for interaction between intervention and an individual-level variable in community randomized trials.
• An instrument to level tissue in paraffin embedding.
• Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c.
• Antibodies that identify only the active conformation of Gi family G protein {alpha} subunits.
• Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms.
• Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival.
• CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.
• Cannabinoids for the treatment of neuropathic pain: Clinical evidence.
• Chemical methods in the evaluation of human contamination.
• Constitutive Activity of the Cannabinoid CB1 Receptor Regulates the Function of Co-expressed Mu Opioid Receptors.
• Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon.
• Epizootiology of trypanosomiases: some aspects of mathematical modelling.
• Exogenous Hsc70, but not thermal preconditioning, confers protection to motoneurons subjected to oxidative stress.
• G protein coupling and ligand selectivity of the D2L and D3 dopamine receptors.
• G-protein-coupled receptors: an update.
• In vitro methods to prepare astrocyte and motoneuron cultures for the investigation of potential in vivo interactions.
• Lucky 13-microtubule depolymerisation by kinesin-13 motors.
• Mallory-Weiss syndrome with esophageal obstruction secondary to adherent intraluminal thrombus.
• Maternal employment, breastfeeding, and health: Evidence from maternity leave mandates.
• Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta(2)-adrenoceptor and the ERK1/2 MAPKs: implications for beta(2)-adrenoceptor signalling via the ERK1/2 MAPKs.
• New aspects of g-protein-coupled receptor signalling and regulation.
• Reactivity of DNA guanyl radicals with phenolate anions.
• Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases.
• Some determinants of attrition in prospective studies on aging.
• The patient's point of view.
• Treatment of psychoneurosis; modified CO2 abreactive technique.
• Urology in a modern health centre.
• Visualisation of a kinesin-13 motor on microtubule end mimics.
• Warburg (HARD +/- E) syndrome without retinal dysplasia: case report and review.
• c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons.