New approaches and recent results concerning human-tissue collagen synthesis.

New approaches and recent results concerning human-tissue collagen synthesis. Research Abstract Details 

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New approaches and recent results concerning human-tissue collagen synthesis. Abstract Text:

Ken Smith,Michael J Rennie,

PURPOSE OF REVIEW: Knowledge of the physiological regulation of human-tissue collagen metabolism in vivo is poor, due to the lack of appropriately robust methods. Recent application of stable isotope tracer techniques to measure human collagen synthesis has provided some insights into the role of nutrition and exercise on collagen turnover in the extracellular matrix of the musculoskeletal system. RECENT FINDINGS: Collagen turnover in the musculoskeletal system is faster than previously thought. Bone collagen synthesis is increased by feeding, whereas both muscle collagen and tendon are unresponsive. Exercise stimulates collagen synthesis in both muscle and tendon in an apparently coordinated manner. There are also sex differences and normal aging is associated with increased muscle collagen synthesis and reductions in bone collagen synthesis, particularly in mature bone collagen. SUMMARY: Collagen turnover appears to be faster than previously thought and is regulated by feeding and exercise, in a tissue-specific manner. Further application of these approaches, coupled with measures of gene and protein expression, to measure the acute regulation of collagen, will lead to a better understanding of the physiology and pathophysiology of human collagen turnover. This is particularly important for developing new therapies to improve bone health and minimize tissue fibrosis.

New approaches and recent results concerning human-tissue collagen synthesis. Publishing Authors By Initials

K Smith,MJ Rennie,

For similar musculoskeletal system: tendons research abstracts see: musculoskeletal system: tendons research

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New approaches and recent results concerning human-tissue collagen synthesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in clinical nutrition and metaboli

VOLUME: 10

Page Numbers: 582-90

Journal Abbreviation:

ISSN: 1363-1950

DAY: 3

MONTH: Sep

YEAR: 2007

New approaches and recent results concerning human-tissue collagen synthesis. Information

Number of References: 55

LANGUAGE: eng

NlmUniqueID: 9804399

New approaches and recent results concerning human-tissue collagen synthesis. Keywords Mesh Terms:

KEYWORDS: Tendons

MESH TERMS: metabolism

Chemical & Substance for Abstract: New approaches and recent results concerning human-tissue collagen synthesis. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for New approaches and recent results concerning human-tissue collagen synthesis.

AFFILIATION: School of Biomedical Sciences, University of Nottingham at Derby Graduate Entry Medical School, Derby, UK. ken.smith@nottingham.ac.uk

Country: England

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MEDLINETA: Curr Opin Clin Nutr Metab Care

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