Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Research Abstract Details 

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Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Abstract Text:

Xiang Xu,Dongji Zhang,Hong Zhang,Paul J Wolters,Nigel P Killeen,Brandon M Sullivan,Richard M Locksley,Clifford A Lowell,George H Caughey,

Mycoplasmas cause chronic inflammation and are implicated in asthma. Mast cells defend against mycoplasma infection and worsen allergic inflammation, which is mediated partly by histamine. To address the hypothesis that mycoplasma provokes histamine release, we exposed mice to Mycoplasma pulmonis, comparing responses in wild-type and mast cell-deficient KitW-sh/KitW-sh (W-sh) mice. Low histamine levels in uninfected W-sh mice confirmed the conventional wisdom that mast cells are principal sources of airway and serum histamine. Although mycoplasma did not release histamine acutely in wild-type airways, levels rose up to 50-fold above baseline 1 week after infection in mice heavily burdened with neutrophils. Surprisingly, histamine levels also rose profoundly in infected W-sh lungs, increasing in parallel with neutrophils and declining with neutrophil depletion. Furthermore, neutrophils from infected airway were highly enriched in histamine compared with naive neutrophils. In vitro, mycoplasma directly stimulated histamine production by naive neutrophils and strongly upregulated mRNA encoding histidine decarboxylase, the rate-limiting enzyme in histamine synthesis. In vivo, treatment with antihistamines pyrilamine or cimetidine decreased lung weight and severity of pneumonia and tracheobronchitis in infected W-sh mice. These findings suggest that neutrophils, provoked by mycoplasma, greatly expand their capacity to synthesize histamine, thereby contributing to lung and airway inflammation.

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Publishing Authors By Initials

X Xu,D Zhang,H Zhang,PJ Wolters,NP Killeen,BM Sullivan,RM Locksley,CA Lowell,GH Caughey,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of experimental medicine

VOLUME: 203

Page Numbers: 2907-17

Journal Abbreviation: J. Exp. Med.

ISSN: 0022-1007

DAY: 11

MONTH: 12

YEAR: 2006

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985109

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: immunology

Chemical & Substance for Abstract: Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Information

Substance Name: Histidine Decarboxylase

Registry Number: EC 4.1.1.22

Grant and Affiliation Information for Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.

AFFILIATION: Cardiovascular Research Institute, Department of Microbiology/Immunology, University of California at San Francisco, and Veterans Affairs Medical Center, San Francisco 94121, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL075026

ACRONYM: HL

MEDLINETA: J Exp Med

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