Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics.

Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Research Abstract Details 

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Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Abstract Text:

Antisense technology constitutes development of sequence-specific DNA or RNA analogs that can block the activity of selected single-stranded genetic sequences and offer the potential of high specificity lacking in many current drug treatments. The sequencing of the human genome has greatly increased the potential of this approach. Antisense oligonucleotides, the most commonly used antisense approach, are unmodified or chemically modified single stranded RNA or DNA molecules specifically designed to hybridize to corresponding RNA by Watson-Crick binding. Phosphorodiamidate Morpholino oligomers (PMO) are a novel class of non-ionic antisense agents that inhibit gene expression by binding to RNA and sterically blocking processing or translation. PMOs have shown excellent efficiency and safety profile via various routes of administration in multiple animal and human studies. This review will summarize the preclinical studies with PMOs on the road to their development as therapeutic agents with particular emphasis on in vivo biodistribution and pharmacokinetics.

Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Publishing Authors By Initials

For similar nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): oligonucleotides, antisense research abstracts see: nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): oligonucleotides, antisense research

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Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current pharmaceutical biotechnology

VOLUME: 5

Page Numbers: 431-9

Journal Abbreviation: Curr Pharm Biotechnol

ISSN: 1389-2010

DAY: 12

MONTH: Oct

YEAR: 2004

Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Information

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LANGUAGE: eng

NlmUniqueID: 100960530

Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Keywords Mesh Terms:

KEYWORDS: Oligonucleotides, Antisense

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Information

Substance Name: Oligonucleotides, Antisense

Registry Number: 0

Grant and Affiliation Information for Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics.

AFFILIATION: Research and Development, AVI BioPharma, Inc., USA. varora@avibio.com

Country: Netherlands

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MEDLINETA: Curr Pharm Biotechnol

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