Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys. Research Abstract Details 

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Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys. Abstract Text:

Wendelien B Oswald,Thomas W Geisbert,Kelly J Davis,Joan B Geisbert,Nancy J Sullivan,Peter B Jahrling,Paul W H I Parren,Dennis R Burton,

Prophylaxis with high doses of neutralizing antibody typically offers protection against challenge with viruses producing acute infections. In this study, we have investigated the ability of the neutralizing human monoclonal antibody, KZ52, to protect against Ebola virus in rhesus macaques. This antibody was previously shown to fully protect guinea pigs from infection. Four rhesus macaques were given 50 mg/kg of neutralizing human monoclonal antibody KZ52 intravenously 1 d before challenge with 1,000 plaque-forming units of Ebola virus, followed by a second dose of 50 mg/kg antibody 4 d after challenge. A control animal was exposed to virus in the absence of antibody treatment. Passive transfer of the neutralizing human monoclonal antibody not only failed to protect macaques against challenge with Ebola virus but also had a minimal effect on the explosive viral replication following infection. We show that the inability of antibody to impact infection was not due to neutralization escape. It appears that Ebola virus has a mechanism of infection propagation in vivo in macaques that is uniquely insensitive even to high concentrations of neutralizing antibody.

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys. Publishing Authors By Initials

WB Oswald,TW Geisbert,KJ Davis,JB Geisbert,NJ Sullivan,PB Jahrling,PW Parren,DR Burton,

For similar diagnosis: laboratory techniques and procedures: immunologic tests: serologic tests: neutralization tests research abstracts see: diagnosis: laboratory techniques and procedures: immunologic tests: serologic tests: neutralization tests research

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Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: PLoS pathogens

VOLUME: 3

Page Numbers: e9

Journal Abbreviation: PLoS Pathog.

ISSN: 1553-7374

DAY: 3

MONTH: Jan

YEAR: 2007

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101238921

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys. Keywords Mesh Terms:

KEYWORDS: Neutralization Tests

MESH TERMS: therapy

Chemical & Substance for Abstract: Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys. Information

Substance Name: Antibodies, Monoclonal

Registry Number: 0

Grant and Affiliation Information for Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.

AFFILIATION: Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America.

Country: United States

AGENCY: United States PHS

GRANT: A148053

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MEDLINETA: PLoS Pathog

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