Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model.

Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. Research Abstract Details 

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Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. Abstract Text:

Ryuta Imaki,Shinichi Niwano,Hiroe Niwano,Daisuke Satoh,Toru Yoshida,Yoshihiko Masaki,Tohru Izumi,

INTRODUCTION: We examined the acute effects of neutral endopeptidase inhibitor on the hemodynamics and electrical properties of dogs subjected to rapid atrial pacing. METHODS: Ten beagle dogs were used and divided into two groups with and without candoxatril, a neutral endopeptidase inhibitor preadministration. Before and after the 6 hours rapid atrial pacing from the right atrial appendage, the hemodynamics, atrial effective refractory period, and monophasic action potential duration of the right atrial appendage were measured and blood samples were collected. Atrial tissue was also excised after the experiment. RESULTS: Candoxatril significantly increased plasma ANP levels (Control: 88.4 +/- 50.25 vs. Candoxatril: 197.1 +/- 32.09 pg/ml, p = 0.004) and prevented reductions in atrial effective refractory period and monophasic action potential duration. We further demonstrated that the treated animals exhibited significantly higher levels of atrial tissue cyclic GMP (Control: 28.1 +/- 1.60 fmol/mg vs. Candoxatril: 44.5 +/- 12.28 fmol/mg, p = 0.034) as well as that of plasma cyclic GMP (Control: 32 +/- 5.5 vs. Candoxatril: 42 +/- 7.1 pg/ml, p = 0.028). CONCLUSION: Candoxatril suppressed the shortening of atrial effective refractory period and monophasic action potential duration in the rapid atrial pacing model. As plasma ANP and the atrial tissue levels of cyclic GMP were higher in the Candoxatril group than the control, this effect was considered to appear through the reduction of calcium overload caused by ANP and cyclic GMP.

Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. Publishing Authors By Initials

R Imaki,S Niwano,H Niwano,D Satoh,T Yoshida,Y Masaki,T Izumi,

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Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Indian pacing and electrophysiology journal

VOLUME: 8

Page Numbers: 102-13

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ISSN: 0972-6292

DAY: 1

MONTH: 04

YEAR: 2008

Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model.

AFFILIATION: Department of Internal Medicine/Cardiology, Kitasato University School of Medicine, Sagamihara, Japan.

Country: India

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MEDLINETA: Indian Pacing Electrophysiol J

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