Neurotrophins, synaptic plasticity and dementia.

Neurotrophins, synaptic plasticity and dementia. Research Abstract Details 

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Neurotrophins, synaptic plasticity and dementia. Abstract Text:

Ottavio Arancio,Moses V Chao,

The growing realization that neurotrophins, such as brain-derived neurotrophic factor (BDNF), are crucial in modulating synaptic plasticity has broadened the spectrum of their trophic actions. At the same time, it has become clear that Abeta peptides derived from amyloid precursor protein (APP) have dramatic effects on synaptic transmission before the onset of the neurodegenerative disease. Because neurotrophins and Abeta are responsible for affecting both synaptic and cognitive function, it is likely that their mechanisms of action will be related and might even intersect. This review highlights several recent findings that suggest trophic factors and APP use similar pathways to control neuronal activity.

Neurotrophins, synaptic plasticity and dementia. Publishing Authors By Initials

O Arancio,MV Chao,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Neurotrophins, synaptic plasticity and dementia. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in neurobiology

VOLUME: 17

Page Numbers: 325-30

Journal Abbreviation: Curr. Opin. Neurobiol.

ISSN: 0959-4388

DAY: 6

MONTH: 04

YEAR: 2007

Neurotrophins, synaptic plasticity and dementia. Information

Number of References: 53

LANGUAGE: eng

NlmUniqueID: 9111376

Neurotrophins, synaptic plasticity and dementia. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Neurotrophins, synaptic plasticity and dementia. Information

Substance Name: Nerve Growth Factors

Registry Number: 0

Grant and Affiliation Information for Neurotrophins, synaptic plasticity and dementia.

AFFILIATION: Department of Pathology and Taub Institute, Columbia University College of Physicians and Surgeons, 630 W168th Street, New York, NY 10032, USA.

Country: England

AGENCY: United States NIA

GRANT: P01AG17490

ACRONYM: AG

MEDLINETA: Curr Opin Neurobiol

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