Neurotrophic factors in neurodegeneration.

Neurotrophic factors in neurodegeneration. Research Abstract Details 

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Neurotrophic factors in neurodegeneration. Abstract Text:

Armin Blesch,

Neurotrophic factors (NTFs) have the unique potential to support neuronal survival and to augment neuronal function in the injured and diseased nervous system. Numerous studies conducted over the last 20 years have provided evidence for the potent therapeutic potential of NTFs in animal models of neurodegenerative diseases. However, major obstacles for the therapeutic use of NTFs are the inability to deliver proteins across the blood-brain-barrier, and dose-limiting adverse effects resulting from the broad exposure of nontargeted structures to NTFs. Two recent developments have allowed NTFs' promise to be truly tested for the first time: first, recent improvements in viral vectors that allow the targeted delivery of NTFs while providing a long-lasting supply and sufficient therapeutic doses of NTFs; and second, improved animal models developed in recent years. In this review, we will discuss some of the potential therapeutic applications of NTFs in neurodegenerative diseases and the potential contribution of disturbed neurotrophic factor signaling to neurodegenerative diseases.

Neurotrophic factors in neurodegeneration. Publishing Authors By Initials

A Blesch,

For similar nervous system diseases: neurodegenerative diseases research abstracts see: nervous system diseases: neurodegenerative diseases research

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Neurotrophic factors in neurodegeneration. Journal Published:

PUBLICATION TYPE: Review

Journal: Brain pathology (Zurich, Switzerland)

VOLUME: 16

Page Numbers: 295-303

Journal Abbreviation: Brain Pathol.

ISSN: 1015-6305

DAY: 3

MONTH: Oct

YEAR: 2006

Neurotrophic factors in neurodegeneration. Information

Number of References: 165

LANGUAGE: eng

NlmUniqueID: 9216781

Neurotrophic factors in neurodegeneration. Keywords Mesh Terms:

KEYWORDS: Neurodegenerative Diseases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Neurotrophic factors in neurodegeneration. Information

Substance Name: Nerve Growth Factors

Registry Number: 0

Grant and Affiliation Information for Neurotrophic factors in neurodegeneration.

AFFILIATION: Department of Neurosciences-0626, Center for Neural Repair, University of California, San Diego, La Jolla, California 92093-0626, USA. ablesch@ucsd.edu

Country: Switzerland

AGENCY: United States NINDS

GRANT: NS46466

ACRONYM: NS

MEDLINETA: Brain Pathol

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