Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications.

Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Research Abstract Details 

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Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Abstract Text:

Darrell W Brann,Krishnan Dhandapani,Chandramohan Wakade,Virendra B Mahesh,Mohammad M Khan,

Estrogen is an important hormone signal that regulates multiple tissues and functions in the body. This review focuses on the neurotrophic and neuroprotective actions of estrogen in the brain, with particular emphasis on estrogen actions in the hippocampus, cerebral cortex and striatum. Sex differences in the risk, onset and severity of neurodegenerative disease such as Alzheimer's disease, Parkinson's disease and stroke are well known, and the potential role of estrogen as a neuroprotective factor is discussed in this context. The review assimilates a complex literature that spans research in humans, non-human primates and rodent animal models and attempts to contrast and compare the findings across species where possible. Current controversies regarding the Women's Health Initiative (WHI) study, its ramifications, concerns and the new studies needed to address these concerns are also addressed. Signaling mechanisms underlying estrogen-induced neuroprotection and synaptic plasticity are reviewed, including the important concepts of genomic versus nongenomic mechanisms, types of estrogen receptor involved and their subcellular targeting, and implicated downstream signaling pathways and mediators. Finally, a multicellular mode of estrogen action in the regulation of neuronal survival and neurotrophism is discussed, as are potential future directions for the field.

Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Publishing Authors By Initials

DW Brann,K Dhandapani,C Wakade,VB Mahesh,MM Khan,

For similar biological phenomena, cell phenomena, and immunity: plant physiology: tropism research abstracts see: biological phenomena, cell phenomena, and immunity: plant physiology: tropism research

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Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Journal Published:

PUBLICATION TYPE: Review

Journal: Steroids

VOLUME: 72

Page Numbers: 381-405

Journal Abbreviation:

ISSN: 0039-128X

DAY: 21

MONTH: 02

YEAR: 2007

Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404536

Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Keywords Mesh Terms:

KEYWORDS: Tropism

MESH TERMS: genetics

Chemical & Substance for Abstract: Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Information

Substance Name: Receptors, Estrogen

Registry Number: 0

Grant and Affiliation Information for Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications.

AFFILIATION: Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, United States. dbrann@mcg.edu

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS050730-02

ACRONYM: NS

MEDLINETA: Steroids

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