Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line.

Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line. Research Abstract Details 

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Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line. Abstract Text:

Akikazu Sakudo,Izuru Nakamura,Deug-Chan Lee,Keiichi Saeki,Kazuyoshi Ikuta,Takashi Onodera,

The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.

Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line. Publishing Authors By Initials

A Sakudo,I Nakamura,DC Lee,K Saeki,K Ikuta,T Onodera,

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Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Protein and peptide letters

VOLUME: 14

Page Numbers: 1-6

Journal Abbreviation: Protein Pept. Lett.

ISSN: 0929-8665

DAY: 1

MONTH: 02

YEAR: 2007

Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line. Information

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LANGUAGE: eng

NlmUniqueID: 9441434

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Grant and Affiliation Information for Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line.

AFFILIATION: Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

Country: Netherlands

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MEDLINETA: Protein Pept Lett

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