Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain.

Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain. Research Abstract Details 

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Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain. Abstract Text:

K B Seroogy,A Mehta,J H Fallon,

The colocalization of neurotensin- and cholecystokinin-like immunoreactivities was demonstrated in neurons of the ventral mesencephalon of the rat by using a double-labeling indirect immunofluorescence procedure for the simultaneous detection of two antigens in the same tissue section. Greater than 90% of the neurotensin-positive perikarya distributed throughout the ventral midbrain (primarily located in the ventral tegmental area, medial substantial nigra, and rostral and caudal linear raphe nuclei) were found to also contain cholecystokinin immunoreactivity. Neurons single-labeled for either peptide were also present, with those immunoreactive for cholecystokinin alone far outnumbering those containing only neurotensin. By combining the double-labeling colocalization technique with fluorescence retrograde tracing, some of the forebrain projections of these neurons were determined. Ventral mesencephalic neurons containing both neurotensin and cholecystokinin were found to project to the nucleus accumbens, prefrontal cortex, or amygdala. The present results, combined with those of previous studies, suggest that there are complex heterogeneous subpopulations of presumed dopaminergic ventral mesencephalic neurons which give rise to the ascending mesotelencephalic systems and which may contain both neurotensin and cholecystokinin, either peptide alone, or neither of these two peptides.

Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain. Publishing Authors By Initials

KB Seroogy,A Mehta,JH Fallon,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains research

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Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 68

Page Numbers: 277-89

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ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1987

Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred Strains

MESH TERMS: analysis

Chemical & Substance for Abstract: Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain. Information

Substance Name: Cholecystokinin

Registry Number: 9011-97-6

Grant and Affiliation Information for Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain.

AFFILIATION: Department of Anatomy and Neurobiology, University of California, Irvine 92717.

Country: GERMANY, WEST

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MEDLINETA: Exp Brain Res

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