Neuropsychological measures in normal individuals that predict subsequent cognitive decline.

Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Research Abstract Details 

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Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Abstract Text:

Deborah Blacker,Hang Lee,Alona Muzikansky,Emily C Martin,Rudolph Tanzi,John J McArdle,Mark Moss,Marilyn Albert,

OBJECTIVE: To examine neuropsychological measures among normal individuals that predict time to subsequent cognitive decline. DESIGN: Cognitive performance, as measured by 6 neuropsychological tests, was examined at baseline. Participants were followed up for approximately 5 years. Cox proportional hazards models were used to evaluate the neuropsychological measures at baseline that predicted time to progression from normal cognition to mild impairment. Comparable data also examined time to progression from mild impairment to a diagnosis of Alzheimer disease. SETTING: Community volunteer-based sample examined at a medical institution. PARTICIPANTS: One hundred and seven individuals who were cognitively normal and 235 individuals with mild cognitive impairment at baseline. MAIN OUTCOME MEASURES: Time to progression from normal cognition to mild impairment and time to progression from mild impairment to a diagnosis of Alzheimer disease. RESULTS: The risk of progressing from normal to mild impairment was considerably greater among those with lower scores on tests of episodic memory (eg, hazard ratio for a 1-SD decrease in the California Verbal Learning Test, 0.55; P<.001). Normal individuals who carried at least 1 copy of the apolipoprotein E epsilon2 allele were less likely to develop cognitive impairments over time than individuals with no epsilon2 allele (hazard ratio for presence of allele, 0.13; P = .006). Measures of both episodic memory and executive function were significant predictors of time to progression from mild impairment to a clinical diagnosis of Alzheimer disease (eg, hazard ratio for a 1-SD decrease in California Verbal Learning Test score, 0.67; P = .005; hazard ratio for a 1-SD increase in the time to complete part B of the Trail Making test, 1.40; P = .007). Among individuals with mild impairments, the apolipoprotein E epsilon4 allele increased risk for Alzheimer disease in a dose-dependent manner; however, this effect was not significant within the context of multivariable models. CONCLUSIONS: Episodic memory performance among normal individuals predicts time to progression to mild impairment while apolipoprotein E epsilon2 status is associated with lower risk of cognitive decline among normal individuals. Tests of both episodic memory and executive function are predictors of time to progression from mild impairment to a clinical diagnosis of Alzheimer disease.

Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Publishing Authors By Initials

D Blacker,H Lee,A Muzikansky,EC Martin,R Tanzi,JJ McArdle,M Moss,M Albert,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

PUBMED ID PMID:

MEDLINE DATE:

Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of neurology

VOLUME: 64

Page Numbers: 862-71

Journal Abbreviation: Arch. Neurol.

ISSN: 0003-9942

DAY: 3

MONTH: Jun

YEAR: 2007

Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372436

Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Information

Substance Name: Apolipoprotein E4

Registry Number: 0

Grant and Affiliation Information for Neuropsychological measures in normal individuals that predict subsequent cognitive decline.

AFFILIATION: Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Country: United States

AGENCY: United States NIA

GRANT: P50 AG05146

ACRONYM: AG

MEDLINETA: Arch Neurol

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