Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings.

Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings. Research Abstract Details 

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Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings. Abstract Text:

Abraham Reichenberg,Philip D Harvey,Abraham Reichenberg,Philip D Harvey,

Until recently, the dominant view was that schizophrenia patients have limited, if any, neuropsychological impairments, and those that are observed are only secondary to the florid symptoms of the disorder. This view has dramatically changed. This review integrates recent evidence demonstrating the severity and profile of neuropsychological impairments in schizophrenia. We present quantitative evaluation of the literature demonstrating that the most severe impairments are apparent in episodic memory and executive control processes, evident on a background of a generalized cognitive deficit. The neuropsychological impairments potentially represent genetic liability to the disorder, as similar, yet milder, impairments are evident in schizophrenia patients even before the onset of psychotic symptoms, as well as in the nonpsychotic relatives of schizophrenia patients. Corresponding cognitive neuroimaging literature on executive functions, episodic memory, and working memory in schizophrenia documenting abnormalities in frontal and medial temporal lobes is summarized, and current models integrating neuropsychological and neuroimaging data are discussed.

Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings. Publishing Authors By Initials

A Reichenberg,PD Harvey,A Reichenberg,PD Harvey,

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Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings. Journal Published:

PUBLICATION TYPE: Review

Journal: Psychological bulletin

VOLUME: 133

Page Numbers: 833-58

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ISSN: 0033-2909

DAY: 28

MONTH: Sep

YEAR: 2007

Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings. Information

Number of References: 375

LANGUAGE: eng

NlmUniqueID: 376473

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Grant and Affiliation Information for Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings.

AFFILIATION: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. avi.reichenberg@mssm.edu

Country: United States

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MEDLINETA: Psychol Bull

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