[Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease]

[Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease] Research Abstract Details 

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[Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease] Abstract Text:

Yong Tang,Shu-Guang Yu,Song Luo,Ting Han,Hai-Yan Yin,

OBJECTIVE: To explore the neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in hippocampus in aged rats with Alzheimer's disease (AD). METHODS: Thirty six aged male rats were randomly divided into normal control group, sham-operated group, untreated group and electroacupuncture group. Animal model of AD was established with fimbria-fornix transection. The rats in the electroacupuncture group received electroacupuncture on Baihui (DU 20), Yongquan (KI 1), Taixi (KI 3) and Xuehai (SP10). The activity of choline acetyltransferase (ChAT) in septal area of brain was detected by radioimmunoassay, and the protein expressions of nerve growth factor (NGF) and c-fos in CA3 region of hippocampus were detected by immunohistochemical assay. RESULTS: The ChAT activity and the expression levels of NGF and c-fos proteins in the electroacupuncture group were significantly higher than those in the untreated group. CONCLUSION: Electroacupuncture therapy can protect cholinergic neurons in hippocampus in aged rats with AD by means of promoting synthesis of c-fos protein and increasing the expression level of NGF.

[Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease] Publishing Authors By Initials

Y Tang,SG Yu,S Luo,T Han,HY Yin,

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[Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhong xi yi jie he xue bao = Journal of Chinese in

VOLUME: 4

Page Numbers: 374-7

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ISSN: 1672-1977

DAY: 12

MONTH: Jul

YEAR: 2006

[Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease] Information

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LANGUAGE: chi

NlmUniqueID: 101199657

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AFFILIATION: Department of Biomedical Engineering, West China Center of Medical Science, Sichuan University, Chengdu, Sichuan Province 610041, China.

Country: China

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MEDLINETA: Zhong Xi Yi Jie He Xue Bao

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