Neurophysiological and clinical aspects of glucocorticoids and memory: a review.

Neurophysiological and clinical aspects of glucocorticoids and memory: a review. Research Abstract Details 

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Neurophysiological and clinical aspects of glucocorticoids and memory: a review. Abstract Text:

Neuropsychologists are increasingly involved in the assessment and treatment of individuals with glucocorticoid (GC) dysfunction. This review examines the clinical and neurophysiological changes associated with alterations in GC levels, with specific emphasis on changes in hippocampal plasticity and memory impairments. Hypothalamic-pituitary-adrenal (HPA) axis regulation of GC production and GC effects at hippocampal receptors are examined. GC-related changes in memory and hippocampal plasticity are considered in a wide array of populations, including animals, healthy adults, patients receiving exogenous GC treatments, and patients with neuropsychiatric disorders resulting in GC dysregulation. Hypotheses regarding GC-related memory changes are considered, with emphasis on hippocampal neurotoxicity and changes in excitatory amino acids, glucose metabolism and neurotrophic factors. These hypotheses are examined, with special attention given to inconsistencies and contradictions within this body of research. Finally, implications for neuropsychological evaluation and future research are presented.

Neurophysiological and clinical aspects of glucocorticoids and memory: a review. Publishing Authors By Initials

For similar endocrine system: endocrine glands: pituitary-adrenal system research abstracts see: endocrine system: endocrine glands: pituitary-adrenal system research

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Neurophysiological and clinical aspects of glucocorticoids and memory: a review. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of clinical and experimental neuropsycholo

VOLUME: 24

Page Numbers: 335-55

Journal Abbreviation:

ISSN: 1380-3395

DAY: 14

MONTH: May

YEAR: 2002

Neurophysiological and clinical aspects of glucocorticoids and memory: a review. Information

Number of References: 110

LANGUAGE: eng

NlmUniqueID: 8502170

Neurophysiological and clinical aspects of glucocorticoids and memory: a review. Keywords Mesh Terms:

KEYWORDS: Pituitary-Adrenal System

MESH TERMS: physiology

Chemical & Substance for Abstract: Neurophysiological and clinical aspects of glucocorticoids and memory: a review. Information

Substance Name: Glucocorticoids

Registry Number: 0

Grant and Affiliation Information for Neurophysiological and clinical aspects of glucocorticoids and memory: a review.

AFFILIATION: Department of Physical Medicine & Rehabilitation, University of Alabama at Birmingham, USA. amy_alderson@shepherd.org

Country: Netherlands

AGENCY: United States NICHD

GRANT: HD07420

ACRONYM: HD

MEDLINETA: J Clin Exp Neuropsychol

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