Neuropeptides in migraine and cluster headache.

Neuropeptides in migraine and cluster headache. Research Abstract Details 

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Neuropeptides in migraine and cluster headache. Abstract Text:

L Edvinsson,P J Goadsby,

The cerebral circulation is invested by a rich network of neuropeptide Y (NPY) and noradrenaline containing sympathetic nerve fibers in arteries, arterioles and veins. However, the nerve supply of vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) containing fibers is sparse. While noradrenaline and NPY cause vasoconstriction, VIP, SP and CGRP are potent vasodilators. Stimulation of the trigeminal ganglion in cat and man elicits release of SP and CGRP. Subjects with spontaneous attacks of migraine show release of CGRP in parallel with headache. Cluster headache patients have release of CGRP and VIP during bouts. Treatment with sumatriptan aborts headache in migraine and cluster headache as well as the concomitant peptide release.

Neuropeptides in migraine and cluster headache. Publishing Authors By Initials

L Edvinsson,PJ Goadsby,

For similar nervous system: peripheral nervous system: autonomic nervous system: sympathetic nervous system: vasomotor system research abstracts see: nervous system: peripheral nervous system: autonomic nervous system: sympathetic nervous system: vasomotor system research

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Neuropeptides in migraine and cluster headache. Journal Published:

PUBLICATION TYPE: Review

Journal: Cephalalgia : an international journal of headache

VOLUME: 14

Page Numbers: 320-7

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: Oct

YEAR: 1994

Neuropeptides in migraine and cluster headache. Information

Number of References: 66

LANGUAGE: eng

NlmUniqueID: 8200710

Neuropeptides in migraine and cluster headache. Keywords Mesh Terms:

KEYWORDS: Vasomotor System

MESH TERMS: physiology

Chemical & Substance for Abstract: Neuropeptides in migraine and cluster headache. Information

Substance Name: Neuropeptides

Registry Number: 0

Grant and Affiliation Information for Neuropeptides in migraine and cluster headache.

AFFILIATION: Department of Internal Medicine, University Hospital, Lund, Sweden.

Country: NORWAY

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MEDLINETA: Cephalalgia

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