Neuronal transcriptome of aplysia: neuronal compartments and circuitry.

Neuronal transcriptome of aplysia: neuronal compartments and circuitry. Research Abstract Details 

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Neuronal transcriptome of aplysia: neuronal compartments and circuitry. Abstract Text:

Leonid L Moroz,John R Edwards,Sathyanarayanan V Puthanveettil,Andrea B Kohn,Thomas Ha,Andreas Heyland,Bjarne Knudsen,Anuj Sahni,Fahong Yu,Li Liu,Sami Jezzini,Peter Lovell,William Iannucculli,Minchen Chen,Tuan Nguyen,Huitao Sheng,Regina Shaw,Sergey Kalachikov,Yuri V Panchin,William Farmerie,James J Russo,Jingyue Ju,Eric R Kandel,

Molecular analyses of Aplysia, a well-established model organism for cellular and systems neural science, have been seriously handicapped by a lack of adequate genomic information. By sequencing cDNA libraries from the central nervous system (CNS), we have identified over 175,000 expressed sequence tags (ESTs), of which 19,814 are unique neuronal gene products and represent 50%-70% of the total Aplysia neuronal transcriptome. We have characterized the transcriptome at three levels: (1) the central nervous system, (2) the elementary components of a simple behavior: the gill-withdrawal reflex-by analyzing sensory, motor, and serotonergic modulatory neurons, and (3) processes of individual neurons. In addition to increasing the amount of available gene sequences of Aplysia by two orders of magnitude, this collection represents the largest database available for any member of the Lophotrochozoa and therefore provides additional insights into evolutionary strategies used by this highly successful diversified lineage, one of the three proposed superclades of bilateral animals.

Neuronal transcriptome of aplysia: neuronal compartments and circuitry. Publishing Authors By Initials

LL Moroz,JR Edwards,SV Puthanveettil,AB Kohn,T Ha,A Heyland,B Knudsen,A Sahni,F Yu,L Liu,S Jezzini,P Lovell,W Iannucculli,M Chen,T Nguyen,H Sheng,R Shaw,S Kalachikov,YV Panchin,W Farmerie,JJ Russo,J Ju,ER Kandel,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Neuronal transcriptome of aplysia: neuronal compartments and circuitry. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cell

VOLUME: 127

Page Numbers: 1453-67

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 29

MONTH: Dec

YEAR: 2006

Neuronal transcriptome of aplysia: neuronal compartments and circuitry. Information

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LANGUAGE: eng

NlmUniqueID: 413066

Neuronal transcriptome of aplysia: neuronal compartments and circuitry. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: physiology

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Grant and Affiliation Information for Neuronal transcriptome of aplysia: neuronal compartments and circuitry.

AFFILIATION: The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St. Augustine, FL 32080, USA. moroz@whitney.ufl.edu

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH075026

ACRONYM: MH

MEDLINETA: Cell

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