Neuronal markers in allergic rhinitis: expression and correlation with sensory testing.

Neuronal markers in allergic rhinitis: expression and correlation with sensory testing. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Neuronal markers in allergic rhinitis: expression and correlation with sensory testing. Abstract Text:

Stephen O'Hanlon,Paul Facer,Karen D Simpson,Guri Sandhu,Hesham A Saleh,Praveen Anand,Stephen O'Hanlon,Paul Facer,Karen D Simpson,Guri Sandhu,Hesham A Saleh,Praveen Anand,

INTRODUCTION: Although the role of immunoglobulin E-mediated hypersensitivity reactions in allergic rhinitis is well known, the relative contribution of sensory nerves to the symptoms of rhinitis is uncertain. This study looked at the level of specific neuronal markers including the nerve marker protein gene product 9.5 (PGP 9.5), sensory and autonomic neuropeptides, the capsaicin/heat receptor TRPV1, and nerve growth factor (NGF) in patients with allergic rhinitis and controls and their correlation with nasal sensitivity. MATERIALS AND METHODS: Forty patients (23 controls, 17 rhinitis) having nasal surgery were recruited. Nasal sensitivity was tested using graded monofilaments. Inferior turbinate biopsies were collected and studied using immunohistology, with measurement of nerve fibers by direct observation or computerized image analysis. RESULTS: Nerve fibers (PGP 9.5) in the epithelium, subepithelium, and glandular/vascular regions were significantly increased in allergic rhinitis (P=.037, <.01, and .04, respectively), as were subepithelial and glandular/vascular fibers immunoreactive for neuropeptide substance P (P=.04 subepithelium; .02 glandular/vascular) and neuropeptide tyrosine (P<.01 glandular/vascular), markers for sensory and sympathetic nerves, respectively. TRPV1 epithelial fiber counts were higher in rhinitis, but this was not statistically significant. Epithelial NGF immunoreactivity (% area) was significantly increased in rhinitis (P=.027). Nasal sensitivity was correlated significantly with PGP 9.5 subepithelial innervation (control touch P=.023, irritation P=.046; rhinitis touch P=.042, irritation P=.043). A correlation was also observed between epithelial NGF and subepithelial PGP 9.5 innervation, which included all subjects (P=.044). CONCLUSION: The increased number and specific phenotypical changes of sensory nerves may play a role in nasal hypersensitivity and provide new targets for the treatment of rhinitis.

Neuronal markers in allergic rhinitis: expression and correlation with sensory testing. Publishing Authors By Initials

S O'Hanlon,P Facer,KD Simpson,G Sandhu,HA Saleh,P Anand,S O'Hanlon,P Facer,KD Simpson,G Sandhu,HA Saleh,P Anand,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Neuronal markers in allergic rhinitis: expression and correlation with sensory testing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Laryngoscope

VOLUME: 117

Page Numbers: 1519-27

Journal Abbreviation: Laryngoscope

ISSN: 0023-852X

DAY: 24

MONTH: Sep

YEAR: 2007

Neuronal markers in allergic rhinitis: expression and correlation with sensory testing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8607378

Neuronal markers in allergic rhinitis: expression and correlation with sensory testing. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Neuronal markers in allergic rhinitis: expression and correlation with sensory testing. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Neuronal markers in allergic rhinitis: expression and correlation with sensory testing.

AFFILIATION: Peripheral Neuropathy Unit, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Laryngoscope

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Neuronal markers in allergic rhinitis: expression and correlation with sensory testing Related Publications

• Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study.
• Anaesthetic neurotoxicity in rodents: is the ketamine controversy real?
• Applying the gender lens to abdominal aortic aneurysm screening.
• Comparison of epilenticular IOL implantation vs technique of anterior and primary posterior capsulorhexis with anterior vitrectomy in paediatric cataract surgery.
• Computer aided analysis of phonocardiogram.
• Current controversies regarding pain assessment in neonates.
• Effect of egg yolk lipids on the freezing of goat semen.
• Fears and beliefs of patients regarding cardiac catheterization.
• Giant villous adenoma presenting as a mass protruding from the rectum in a 29-year-old female patient.
• Impact of external haematology proficiency testing programme on quality of laboratories.
• Is too much neurohormonal blockade harmful?
• Isolated intraorbital metastasis in breast carcinoma.
• Labelled cleanable sheeting to facilitate microvascular clamp identification.
• Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database.
• Malaria parasite burden and treatment seeking behavior in ethnic communities of Assam, Northeastern India.
• Mechanisms of synergy between alcohol and hepatitis C virus.
• Microwave enhanced polarization in a carbon dioxide molecule.
• Neurobehavior of preterm infants at 36 weeks postconception as a function of morphine analgesia.
• Neurodevelopmental changes of fetal pain.
• Neuronal markers in allergic rhinitis: expression and correlation with sensory testing.
• Non-pharmacological techniques for pain management in neonates.
• Pain assessment in preterm neonates.
• Pharmacological approaches to the management of pain in the neonatal intensive care unit.
• Premedication for tracheal intubation in neonates: confusion or controversy?
• Seeing through the blind! Ability of hospital staff to differentiate morphine from placebo, in neonates at a placebo controlled trial.
• Sex and gender subgroup analyses of randomized trials the need to proceed with caution.
• Studies on sorption of Cd(II) on Tata chromite mine overburden.
• Voltage-gated ion channel Na(v)1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).
• Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies.
• Yoga in premature ejaculation: a comparative trial with fluoxetine.