Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.

Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Research Abstract Details 

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Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Abstract Text:

Yunfei Huang,Daniel S Higginson,Lynda Hester,Myung Hee Park,Solomon H Snyder,Yunfei Huang,Daniel S Higginson,Lynda Hester,Myung Hee Park,Solomon H Snyder,

Eukaryotic translation initiation factor 5A (eIF5A), the only known protein containing the polyamine-derived amino acid hypusine, modulates protein synthesis. We show that neurotrophic and neuroprotective actions of nerve growth factor (NGF) are mediated by hypusinated eIF5A, which can account for the known roles of polyamines in cell growth and survival. NGF treatment of PC12 cells stimulates eIF5A formation. Moreover, prevention of hypusine formation by a selective inhibitor of deoxyhypusine synthase and by its depletion with RNA interference blocks the NGF-elicited augmentation of neurite outgrowth and cell survival of PC12 cells. In brain cultures, inhibition of hypusine formation also inhibits neuronal process extension.

Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Publishing Authors By Initials

Y Huang,DS Higginson,L Hester,MH Park,SH Snyder,Y Huang,DS Higginson,L Hester,MH Park,SH Snyder,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 4194-9

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 28

MONTH: 02

YEAR: 2007

Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: metabolism

Chemical & Substance for Abstract: Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Information

Substance Name: Arginase

Registry Number: EC 3.5.3.1

Grant and Affiliation Information for Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.

AFFILIATION: Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH 18501

ACRONYM: MH

MEDLINETA: Proc Natl Acad Sci U S A

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