Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17.

Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Abstract Text:

Magali Irla,Murielle Saade,Carla Fernandez,Lionel Chasson, Victorero,Nadia Dahmane, Chazal,Catherine Nguyen,Magali Irla,Murielle Saade,Carla Fernandez,Lionel Chasson, Victorero,Nadia Dahmane, Chazal,Catherine Nguyen,Magali Irla,Murielle Saade,Carla Fernandez,Lionel Chasson, Victorero,Nadia Dahmane, Chazal,Catherine Nguyen,

We identified the Spatial (Stromal Protein Associated with Thymii and Lymph-node) gene from an adult thymus mouse library of cDNA clones. By RT-PCR, we reported that Spatial was highly expressed in restricted areas of the central nervous system. Here, we characterize the precise cellular localization of Spatial during mouse brain development in the cerebellum, hippocampus and cortex. Five different transcript isoforms have been described for Spatial and among those, only Spatial-epsilon and -beta present a tightly controlled expression. In the cerebellum, Spatial expression is detected in the external precursor granular layer and persists as these cells migrate and differentiate to form the internal granular layer. It is also expressed in differentiating Purkinje cells with a specific somatodendritic distribution. Spatial expression in the hippocampus is spatially and temporally regulated: it is first expressed in the CA3 field, then in CA1 and later in the dentate gyrus. Interestingly, Spatial-beta expression tightly overlaps with the beginning of neuronal differentiation in both structures. Using cultured hippocampal neurons, we show that Spatial also exhibits a somatodendritic distribution and it is concentrated in some synaptic regions. Moreover, the vesicle-like cellular distribution of Spatial protein in dendrites is similar to that described for the kinesin motor protein KIF17. Immunofluorescence analyses show that Spatial colocalizes with KIF17 in dendrites of hippocampal neurons in primary culture. Additionally, coimmunoprecipitation experiments of endogenous proteins from hippocampus confirmed that Spatial and KIF17 physically interact. These findings suggest that Spatial may play a role in neuronal morphogenesis and synaptic plasticity through its interaction with the kinesin motor KIF17 in dendrites.

Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Publishing Authors By Initials

M Irla,M Saade,C Fernandez,L Chasson,G Victorero,N Dahmane,G Chazal,C Nguyen,M Irla,M Saade,C Fernandez,L Chasson,G Victorero,N Dahmane,G Chazal,C Nguyen,M Irla,M Saade,C Fernandez,L Chasson,G Victorero,N Dahmane,G Chazal,C Nguyen,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental cell research

VOLUME: 313

Page Numbers: 4107-19

Journal Abbreviation: Exp. Cell Res.

ISSN: 0014-4827

DAY: 20

MONTH: 09

YEAR: 2007

Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 373226

Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17.

AFFILIATION: INSERM-ERM206, laboratoire TAGC, Case 928, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Cell Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Neuronal distribution of Spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17 Related Publications

• A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole.
• A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity.
• Bilateral asymmetries in clinical measures of lower-extremity anatomic characteristics.
• Brain and upper extremity PET/CT findings of hyperglycemia-induced hemiballism-hemichorea.
• Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients.
• Cerebral venous congestion as indication for thrombolytic treatment.
• Cytology of papillary low-grade transitional cell carcinoma of the cervix in pap smear.
• Decentralized sanitation implementation in Vietnam: a peri-urban case study.
• Discordance of longitudinal changes in bone density between densitometers.
• ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation.
• Effect of Single Vs. Multiple Sets for Strength: 2507: Board #54 June 2 9:30 AM - 11:00 AM.
• F-18 FDG PET/CT staging of multiple myeloma with diffuse osseous and extramedullary lesions.
• Innovations: geriatric psychiatry: diagnosis and treatment of neuropsychiatric symptoms in Alzheimer's disease.
• Interstitial fluids associated with wound repair support proliferation but not differentiation of neonatal rat myoblasts in vitro.
• Lipoprotein effects of combined ezetimibe and colesevelam hydrochloride versus ezetimibe alone in hypercholesterolemic subjects: a pilot study.
• Long-term survival of patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoinfusion.
• Neurocognitive and social cognitive correlates of formal thought disorder in schizophrenia patients.
• Nonlinear relationship between length of residence and depression in a community-based sample of Vietnamese Americans.
• On appetite and its loss.
• PET/CT characterization and monitoring of disease activity in lymphomatoid granulomatosis.
• Punctate inner choroidopathy: a survey analysis of 77 persons.
• Risk factors for placental abruption in a socio-economically disadvantaged region.
• Sensitivity of dynamical systems to parameters in a convex subset of a topological vector space.
• The (pro)renin receptor: a new kid in town.
• The Relationship Between Strength And Explosiveness: 1794: Board #82 May 31 9:00 AM 10:30 AM.
• The role of intra-operative motor evoked potentials in the optimization of chronic cortical stimulation for the treatment of neuropathic pain.
• Unexpected tracheal web encountered during difficult intubation in the operating room.
• Wireless Real-Time Head Movement System Using a Personal Digital Assistant (PDA) for Control of a Power Wheelchair.
• Wireless Real-Time Head Movement System Using a Personal Digital Assistant (PDA) for Control of a Power Wheelchair.
• [Expressions of type I and type III collagens and tenascin-C in rat bone mesenchymal stem cells co-cultured with ligament fibroblasts]