Neuronal competition for action potential initiation sites in a circuit controlling simple learning.

Neuronal competition for action potential initiation sites in a circuit controlling simple learning. Research Abstract Details 

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Neuronal competition for action potential initiation sites in a circuit controlling simple learning. Abstract Text:

G E Cruz,C L Sahley,K J Muller,G E Cruz,C L Sahley,K J Muller,

The spatial and temporal patterns of action potential initiations were studied in a behaving leech preparation to determine the basis of increased firing that accompanies sensitization, a form of non-associative learning requiring the S-interneurons. Little is known at the network level about mechanisms of behavioral sensitization. The S-interneurons, one in each ganglion and linked by electrical synapses with both neighbors to form a chain, are interposed between sensory and motor neurons. In sensitized preparations the strength of shortening is related to S-cell firing, which itself is the result of impulses initiating in several S-cells. Because the S-cells, as independent initiation sites, all contribute to activity in the chain, it was hypothesized that during sensitization, increased multi-site activity increased the chain's firing rate. However, it was found that during sensitization, the single site with the largest initiation rate, the S-cell in the stimulated segment, suppressed initiations in adjacent ganglia. Experiments showed this was both because (1) it received the earliest, greatest input and (2) the delayed synaptic input to the adjacent S-cells coincided with the action potential refractory period. A compartmental model of the S-cell and its inputs showed that a simple, intrinsic mechanism of inexcitability after each action potential may account for suppression of impulse initiations. Thus, a non-synaptic competition between neurons alters synaptic integration in the chain. In one mode, inputs to different sites sum independently, whereas in another, synaptic input to a single site precisely specifies the overall pattern of activity.

Neuronal competition for action potential initiation sites in a circuit controlling simple learning. Publishing Authors By Initials

GE Cruz,CL Sahley,KJ Muller,GE Cruz,CL Sahley,KJ Muller,

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Neuronal competition for action potential initiation sites in a circuit controlling simple learning. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience

VOLUME: 148

Page Numbers: 65-81

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 17

MONTH: 07

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7605074

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Grant and Affiliation Information for Neuronal competition for action potential initiation sites in a circuit controlling simple learning.

AFFILIATION: Department of Physiology and Biophysics, University of Miami School of Medicine, P.O. Box 016430 (R-430), Miami, FL 33136, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01-NS34927

ACRONYM: NS

MEDLINETA: Neuroscience

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