Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia.

Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia. Research Abstract Details 

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Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia. Abstract Text:

Sabina Berretta,Harry Pantazopoulos,Nicholas Lange,

BACKGROUND: Growing evidence supports a pivotal role for the amygdala in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ). However, the occurrence of morphologic changes in the amygdala is currently controversial. METHODS: Total number and numeric density of neurons, neuronal somata size, and volume of the lateral (LN), basal (BN), accessory basal (ABN), and cortical (CO) nuclei of the amygdala were measured in 12 normal control, 10 BD, and 16 SZ subjects. RESULTS: In BD subjects, reductions of total numbers (41.1%; p = .01) and numeric densities of neurons (14.5%, p = .01), as well as volume (29.0%; p = .01), were detected in LN. Density of neurons was also decreased in ABN of the same subjects (20.8%; p = .0005). These changes were not related to antipsychotics or lithium salt exposure. In SZ subjects, a decrease of total numbers of neurons was detected in LN (23.6%; p = .04). This effect was no longer significant once exposure to antipsychotics was taken into account. CONCLUSIONS: These findings offer structural evidence for an involvement of the amygdala in BD. Consequent loss of amygdalar function may account for abnormalities in emotion processing typical of BD subjects. In contrast, changes in SZ were limited and may have been induced by pharmacologic treatment.

Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia. Publishing Authors By Initials

S Berretta,H Pantazopoulos,N Lange,

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Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 62

Page Numbers: 884-93

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 14

MONTH: 08

YEAR: 2007

Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia.

AFFILIATION: Translational Neuroscience Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA. s.berretta@mclean.harvard.edu

Country: United States

AGENCY: United States NIMH

GRANT: R24MH068855

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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