Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding.

Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Research Abstract Details 

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Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Abstract Text:

Hongkui Zeng,Alexander Gragerov,John G Hohmann,Maria N Pavlova,Brian A Schimpf,Hui Xu,Long-Jun Wu,Hiroki Toyoda,Ming-Gao Zhao,Alex D Rohde,Galina Gragerova,Rene Onrust,John E Bergmann,Min Zhuo,George A Gaitanaris,

Neuromedin U (NMU) is a highly conserved neuropeptide with a variety of physiological functions mediated by two receptors, peripheral NMUR1 and central nervous system NMUR2. Here we report the generation and phenotypic characterization of mice deficient in the central nervous system receptor NMUR2. We show that behavioral effects, such as suppression of food intake, enhanced pain response, and excessive grooming induced by intracerebroventricular NMU administration were abolished in the NMUR2 knockout (KO) mice, establishing a causal role for NMUR2 in mediating NMU's central effects on these behaviors. In contrast to the NMU peptide-deficient mice, NMUR2 KO mice appeared normal with regard to stress, anxiety, body weight regulation, and food consumption. However, the NMUR2 KO mice showed reduced pain sensitivity in both the hot plate and formalin tests. Furthermore, facilitated excitatory synaptic transmission in spinal dorsal horn neurons, a mechanism by which NMU stimulates pain, did not occur in NMUR2 KO mice. These results provide significant insights into a functional dissection of the differential contribution of peripherally or centrally acting NMU system. They suggest that NMUR2 plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding.

Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Publishing Authors By Initials

H Zeng,A Gragerov,JG Hohmann,MN Pavlova,BA Schimpf,H Xu,LJ Wu,H Toyoda,MG Zhao,AD Rohde,G Gragerova,R Onrust,JE Bergmann,M Zhuo,GA Gaitanaris,

For similar pathological conditions, signs and symptoms: pathologic processes: stress research abstracts see: pathological conditions, signs and symptoms: pathologic processes: stress research

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Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 26

Page Numbers: 9352-63

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 9

MONTH: 10

YEAR: 2006

Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Keywords Mesh Terms:

KEYWORDS: Stress

MESH TERMS: genetics

Chemical & Substance for Abstract: Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Information

Substance Name: neuromedin U receptor

Registry Number: 0

Grant and Affiliation Information for Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding.

AFFILIATION: Nura, Inc., Seattle, WA 98104, USA. hzeng@omeros.com

Country: United States

AGENCY: United States NIMH

GRANT: MH070241

ACRONYM: MH

MEDLINETA: Mol Cell Biol

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