Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective.

Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective. Research Abstract Details 

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Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective. Abstract Text:

Annelies Van Rie,Patrick R Harrington,Anna Dow,Kevin Robertson,

Neurodevelopmental abnormalities associated with HIV infection have been described since the first reports of pediatric AIDS in the 1980s. Before antiretroviral therapy (ART) became widely available, progressive HIV-1 encephalopathy (PHE) was reported in the US in 13-35% of children with HIV-1 infection and in 35-50% of children with AIDS. Introduction of ART can prevent PHE and reverse PHE present at ART initiation, but a high prevalence of residual problems has been described. Even though 90% of HIV-infected children live in the developing world, few children have access to ART and little is known regarding the neurological manifestations of perinatal HIV infection in those regions. Mechanisms of pediatric HIV-1 neuropathogenesis and factors associated with neurodevelopmental abnormalities in perinatally infected children are not yet fully understood. Studies have demonstrated that HIV-1 enters the CNS soon after infection and may persist in this compartment over the entire course of HIV-1 infection. The CNS is a distinct viral reservoir, differing from peripheral compartments in target cells and antiretroviral penetration. Neurotropic HIV-1 likely develops distinct genotypic characteristics in response to this unique environment. We reviewed the literature on pediatric neuroAIDS and identified gaps in the current knowledge.

Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective. Publishing Authors By Initials

A Van Rie,PR Harrington,A Dow,K Robertson,

For similar nervous system diseases research abstracts see: nervous system diseases research

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Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective. Journal Published:

PUBLICATION TYPE: Review

Journal: European journal of paediatric neurology : EJPN :

VOLUME: 11

Page Numbers: 1-9

Journal Abbreviation: Eur. J. Paediatr. Neurol.

ISSN: 1090-3798

DAY: 29

MONTH: 11

YEAR: 2006

Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective. Information

Number of References: 128

LANGUAGE: eng

NlmUniqueID: 9715169

Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective. Keywords Mesh Terms:

KEYWORDS: Nervous System Diseases

MESH TERMS: virology

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Grant and Affiliation Information for Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective.

AFFILIATION: Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, 2104F Mc Gavran-Greenberg Hall, Chapel Hill, NC 27599-7435, USA. vanrie@email.unc.edu

Country: England

AGENCY: United States FIC

GRANT: R21 TW06682

ACRONYM: TW

MEDLINETA: Eur J Paediatr Neurol

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