Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report.

Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report. Research Abstract Details 

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Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report. Abstract Text:

Monica S Vavilala,Saipin Muangman,Pichaya Waitayawinyu,Ceceila Roscigno,Kenneth Jaffe,Pamela Mitchell,Catherine Kirkness,Jerry J Zimmerman,Richard Ellenbogen,Arthur M Lam,

The objective of this report is to describe cerebral autoregulation after severe inflicted pediatric traumatic brain injury (iTBI). We examined cerebral autoregulation of both cerebral hemispheres (mean autoregulatory index; ARI) in children <5 years with Glasgow Coma Scale (GCS) score of <9 and no evidence of brain death within the first 48 h of pediatric intensive care unit (PICU) admission. Discharge and 6-month Glasgow Outcome Scale (GOS) scores were collected. GOS of <4 reflected poor outcome. All three iTBI and all seven noninflicted TBI (nTBI) patients had admission GCS score of <9. Eight of 10 patients had Autoregulatory Index (ARI) of <0.4 (impaired cerebral autoregulation) of at least one hemisphere. All children with iTBI had poor outcome, and none had intact cerebral autoregulation in both hemispheres. Children with nTBI had better overall outcome than those with iTBI. Two of the children with nTBI had intact autoregulation in both hemispheres and good outcome. Two of the three children with iTBI had differential effects on autoregulation between hemispheres despite bilateral injury. These are, to our knowledge, the first data on cerebral blood flow autoregulation in the unique setting of iTBI and provide a rationale for further study of their relationship to outcome and effects of therapy.

Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report. Publishing Authors By Initials

MS Vavilala,S Muangman,P Waitayawinyu,C Roscigno,K Jaffe,P Mitchell,C Kirkness,JJ Zimmerman,R Ellenbogen,AM Lam,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurotrauma

VOLUME: 24

Page Numbers: 87-96

Journal Abbreviation: J. Neurotrauma

ISSN: 0897-7151

DAY: 3

MONTH: Jan

YEAR: 2007

Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report. Information

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LANGUAGE: eng

NlmUniqueID: 8811626

Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: physiopathology

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Grant and Affiliation Information for Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report.

AFFILIATION: Department of Anesthesiology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA. vavilala@u.washington.edu

Country: United States

AGENCY: United States NICHD

GRANT: 5K23 HD 0044632-03

ACRONYM: HD

MEDLINETA: J Neurotrauma

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