Neuroimaging findings in twins discordant for Alzheimer's disease.

Neuroimaging findings in twins discordant for Alzheimer's disease. Research Abstract Details 

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Neuroimaging findings in twins discordant for Alzheimer's disease. Abstract Text:

N L Pedersen,B L Miller,J L Wetherell,J Vallo,A W Toga,N Knutson,C M Mehringer,G W Small,M Gatz,

Data from computed tomography (CT) scans of 12 twin pairs in which one partner had Azheimer's disease (AD) and the other partner is cognitively intact were analyzed to study structural brain features associated with AD while controlling for familial factors. Visual ratings and analysis of quantified areas and volumes indicated that AD twins showed more dilation of temporal horns, lateral ventricles and third ventricle, and more atrophy of temporal lobes, particularly in the anterior temporal/perisylvian area, than their healthy cotwins. Demented twins did not have smaller intracranial areas or overall brain volumes than their intact partners. The apolipoprotein sigma-4 allele was associated with greater dilation of lateral ventricles and ventricular volume. Significant intrapair correlations were found for total intracranial area and volume, cerebellar area and white matter lesions.

Neuroimaging findings in twins discordant for Alzheimer's disease. Publishing Authors By Initials

NL Pedersen,BL Miller,JL Wetherell,J Vallo,AW Toga,N Knutson,CM Mehringer,GW Small,M Gatz,

For similar reproductive and urinary physiology: reproduction: pregnancy: pregnancy, multiple: twins: twins, dizygotic research abstracts see: reproductive and urinary physiology: reproduction: pregnancy: pregnancy, multiple: twins: twins, dizygotic research

PUBMED ID PMID:

MEDLINE DATE: 1999 Jan-Feb

Neuroimaging findings in twins discordant for Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Twin Study

Journal: Dementia and geriatric cognitive disorders

VOLUME: 10

Page Numbers: 51-8

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2008

Neuroimaging findings in twins discordant for Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Neuroimaging findings in twins discordant for Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Twins, Dizygotic

MESH TERMS: radiography

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Grant and Affiliation Information for Neuroimaging findings in twins discordant for Alzheimer's disease.

AFFILIATION: Department of Psychology, University of Southern California, Los Angeles, Calif., USA.

Country: SWITZERLAND

AGENCY: United States NCRR

GRANT: R01 RR05956

ACRONYM: RR

MEDLINETA: Dement Geriatr Cogn Disord

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