Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation.

Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. Abstract Text:

The proneuronal gene neurogenin 1 (ngn1) is essential for development of the inner-ear sensory neurons that are completely absent in ngn1 null mutants. Neither afferent, efferent, nor autonomic nerve fibers were detected in the ears of ngn1 null mutants. We suggest that efferent and autonomic fibers are lost secondarily to the absence of afferents. In this article we show that ngn1 null mutants develop smaller sensory epithelia with morphologically normal hair cells. In particular, the saccule is reduced dramatically and forms only a small recess with few hair cells along a duct connecting the utricle with the cochlea. Hair cells of newborn ngn1 null mutants show no structural abnormalities, suggesting that embryonic development of hair cells is independent of innervation. However, the less regular pattern of dispersal within sensory epithelia may be caused by some effects of afferents or to the stunted growth of the sensory epithelia. Tracing of facial and stato-acoustic nerves in control and ngn1 null mutants showed that only the distal, epibranchial, placode-derived sensory neurons of the geniculate ganglion exist in mutants. Tracing further showed that these geniculate ganglion neurons project exclusively to the solitary tract. In addition to the normal complement of facial branchial and visceral motoneurons, ngnl null mutants have some trigeminal motoneurons and contralateral inner-ear efferents projecting, at least temporarily, through the facial nerve. These data suggest that some neurons in the brainstem (e.g., inner-ear efferents, trigeminal motoneurons) require afferents to grow along and redirect to ectopic cranial nerve roots in the absence of their corresponding sensory roots.

Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. Publishing Authors By Initials

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

PUBMED ID PMID:

MEDLINE DATE:

Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the Association for Research in Otolary

VOLUME: 1

Page Numbers: 129-43

Journal Abbreviation: J. Assoc. Res. Otolaryngol.

ISSN: 1525-3961

DAY: 17

MONTH: Sep

YEAR: 2000

Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892857

Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: pathology

Chemical & Substance for Abstract: Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. Information

Substance Name: Neurog1 protein, mouse

Registry Number: 182238-50-2

Grant and Affiliation Information for Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation.

AFFILIATION: Dana Farber Cancer Institute, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NIDCD

GRANT: 2P01 DC00215-14A1

ACRONYM: DC

MEDLINETA: J Assoc Res Otolaryngol

REFSOURCE: J Assoc Res Otolaryngol 2000 Dec;1(4):32

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation Related Publications

• Adaptations of the vestibular system to short and long-term exposures to altered gravity.
• Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation.
• Long-Distance Three-Color Neuronal Tracing in Fixed Tissue Using NeuroVue Dyes.
• Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons.
• Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation.
• Regenerating cochlear hair cells: quo vadis stem cell.
• Stem cells and molecular strategies to restore hearing.
• The molecular biology of ear development - "Twenty years are nothing".
• [Clinical experience with the "Grevimun" immunologic pregnancy test (SSW)]
• [Fundus changes in late toxemias of pregnancy]
• [Graduation of gynecological findings from the social-gynecological and industrial health viewpoint (author's transl)]
• [Homeoplastic endometrium transplantations at the Berlin University Gynecologic Clinic (Charité) during 1948-1968]
• [Malate dehydrogenase determination in obstetrics]
• [Noise and pregnancy (author's transl)]
• [On labor induction by intravenous estrogen administration]
• [On the morphology and clinical course of placenta increta]
• [Results of sociogynaecological examination for fitness of working women (author's transl)]
• [Serum activity of alkaline and acid phosphatase in pregnancy and during delivery]
• [Serum activity of transaminase (SGOT, SGPT) and lactate dehydrogenase (SLDH) in normal pregnancy and during delivery]
• [The TTC-test as screening test for the determination of bacteriurias in pregnancy]
• [The use of controlled hypothermia in the treatment of eclampsia]