Neurofibromin as a regulator of melanocyte development and differentiation.

Neurofibromin as a regulator of melanocyte development and differentiation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Neurofibromin as a regulator of melanocyte development and differentiation. Abstract Text:

Ganesh Diwakar,Deming Zhang,Shunlin Jiang,Thomas J Hornyak,

Patients with the genetic disease type I neurofibromatosis (NF1) exhibit characteristic pigmentary lesions associated with loss of a single allele of NF1, encoding the 260 kDa protein neurofibromin. To understand the basis for these pigmentary problems, the properties of melanocytes haploinsufficient for the murine gene Nf1 were studied using Nf1(+/-) knockout mice. We demonstrate that neurofibromin regulates the Kit-Mitf signaling axis in vivo during melanocyte development. Primary Nf1(+/-) melanocytes were purified by FACS to measure melanogenic gene expression. We found that Nf1(+/-) melanocytes exhibit higher levels of melanogenic gene expression than their wild-type counterparts. Both prior to and following Kit stimulation, Nf1(+/-) melanocytes also exhibit increased activation of the MAP kinase pathway compared with primary cells. The melanogenic response of primary melanocytes to Mek inhibition is consistent with the changes observed with Nf1 haploinsufficiency; however, these changes differ from those observed with their immortalized counterparts. The observation that reduction of neurofibromin, either from haploinsufficiency in the case of primary melanocytes or from neurofibromin knockdown in the case of melan-a cells, enhances melanogenic gene expression suggests that neurofibromin plays a dominant role to MEK activity in controlling melanogenic gene expression in murine melanocytes.

Neurofibromin as a regulator of melanocyte development and differentiation. Publishing Authors By Initials

G Diwakar,D Zhang,S Jiang,TJ Hornyak,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Neurofibromin as a regulator of melanocyte development and differentiation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cell science

VOLUME: 121

Page Numbers: 167-77

Journal Abbreviation: J. Cell. Sci.

ISSN: 0021-9533

DAY: 18

MONTH: 12

YEAR: 2007

Neurofibromin as a regulator of melanocyte development and differentiation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 52457

Neurofibromin as a regulator of melanocyte development and differentiation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Neurofibromin as a regulator of melanocyte development and differentiation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Neurofibromin as a regulator of melanocyte development and differentiation.

AFFILIATION: Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Cell Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Neurofibromin as a regulator of melanocyte development and differentiation Related Publications

• Controversial topic: Return to competitive sport after severe traumatic brain injury.
• Effect of illicit recreational drugs upon sleep: Cocaine, ecstasy and marijuana.
• Energy. Roping the Sun.
• Neurofibromin as a regulator of melanocyte development and differentiation.
• RFID powder.
• Restless legs syndrome in older adults.
• Sensitized luminescence of trivalent lanthanide complexes eu3+/quinaldinic Acid and eu3+/1,4-dihydro-oxo-chinoline-3-carboxilic Acid.