Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis).

Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis). Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis). Abstract Text:

Glutamate receptors (GluRs) have been implicated in brain function and pathology. Their presence in peripheral tissues suggests a vital role in the pathophysiology of various organ systems. In earlier studies, the authors reported the differential distribution of ionotropic and metabotropic GluRs in neural and nonneural peripheral tissues of the rat. In this study, they investigated the presence and the localization of the GluRs in the reproductive organs of Macaca fascicularis. The data illustrate the presence of the GluR 2/3, metabotropic glutamate receptor 2/3, kainate 2, and N-methyl-D-aspartate receptor 1 (NMDAR 1). These are localized in the different structures of the ovaries, uterine cervix, myometrium, endometrium, and inflammatory cells. Smooth muscle of the myometrium and arterioles showed strong immunolabeling with anti-GluR 2/3 and, to a lesser intensity, with the other ionotropic glutamate receptor antibodies. NMDAR 1 showed the most widespread staining in all the structures. Mast cells showed strong immunolabeling with the anti-NMDA antibody. The demonstration and the differential expression of GluRs in the female reproductive system of nonhuman primate experimental models provide first evidence suggesting excitatory signaling in these tissues.

Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis). Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Toxicologic pathology

VOLUME: 36

Page Numbers: 478-84

Journal Abbreviation:

ISSN: 1533-1601

DAY: 15

MONTH: 04

YEAR: 2008

Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905907

Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis). Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis). Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis).

AFFILIATION: Health Canada, Toxicology Research Division, Ottawa, Ontario, Canada. santokh_gill@hc-sc.gc.ca

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Toxicol Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Neuroexcitatory targets in the female reproductive system of the nonhuman primate Macaca fascicularis Related Publications

• A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity.
• Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.
• Asymptomatic renal cell carcinoma as a finding of Bardet Biedl syndrome.
• Diffuse placoid choroidopathy in a patient with common variable immunodeficiency.
• Domoic acid toxicologic pathology: a review.
• Early virologic rebound in a pilot trial of ritonavir-boosted atanazavir as maintenance monotherapy.
• Enhancement of Ovulatory Follicle Development in Maiden Sheep by Short-term Supplementation with Steam-flaked Corn.
• Immune cells in the human choroid.
• Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis).
• Patients' perception and effectiveness of a treatment containing enfuvirtide when used in HIV-infected patients without very advanced disease.
• Regional susceptibility to domoic acid in primary astrocyte cells cultured from the brain stem and hippocampus.
• Regression of radiation-induced macular edema after systemic bevacizumab.
• Reply.
• Retinal topography and thickness mapping in atrophic age related macular degeneration.
• Sulcus-based 25-gauge vitrectomy with transscleral intraocular lens fixation.
• Toxicological effects of in utero and lactational exposure of rats to a mixture of environmental contaminants detected in canadian arctic human populations.
• [The International System of Units]
• [The contribution of reviewers and editors to the scientific work of the authors]