Neuroendocrine measures of dopaminergic function in chronic cocaine users.

Neuroendocrine measures of dopaminergic function in chronic cocaine users. Research Abstract Details 

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Neuroendocrine measures of dopaminergic function in chronic cocaine users. Abstract Text:

Plasma prolactin (PRL) and growth hormone (GH) levels are determined, in part, by the effects of dopamine (DA) at pituitary and hypothalamic DA receptors, respectively. To determine if chronic cocaine abuse alters dopaminergic activity, basal PRL and GH concentrations were measured in 16 male patients meeting DSM-III-R criteria for cocaine dependence (8 cocaine users and 8 cocaine + alcohol users) and 8 normal controls. In addition, the functional responsivity of DA receptors was assessed in the same group of patients by measuring the change in plasma PRL and GH concentrations following the administration of the direct-acting DA agonist, apomorphine (0.01 mg/kg, s.c.) or saline. No difference in basal plasma PRL and GH levels or plasma PRL and GH responses to apomorphine administration was found between the entire group of cocaine patients and normal controls. However, three of the cocaine patients had basal plasma PRL levels that were more than 2.5 SD greater than that of the normal controls, suggesting that some interference of dopaminergic inhibition of PRL secretion might be present in at least some cocaine users. Although baseline plasma PRL levels were elevated in a subgroup of cocaine users, these data do not support the hypothesis that chronic cocaine abuse produces consistent abnormalities in dopaminergic function at the pituitary or hypothalamus.

Neuroendocrine measures of dopaminergic function in chronic cocaine users. Publishing Authors By Initials

For similar disorders of environmental origin: substance-related disorders research abstracts see: disorders of environmental origin: substance-related disorders research

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Neuroendocrine measures of dopaminergic function in chronic cocaine users. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Psychiatry research

VOLUME: 33

Page Numbers: 151-9

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Aug

YEAR: 1990

Neuroendocrine measures of dopaminergic function in chronic cocaine users. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7911385

Neuroendocrine measures of dopaminergic function in chronic cocaine users. Keywords Mesh Terms:

KEYWORDS: Substance-Related Disorders

MESH TERMS: blood

Chemical & Substance for Abstract: Neuroendocrine measures of dopaminergic function in chronic cocaine users. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Neuroendocrine measures of dopaminergic function in chronic cocaine users.

AFFILIATION: Department of Psychiatry, Case Western Reserve University, Cleveland, OH.

Country: IRELAND

AGENCY: United States NCRR

GRANT: MO1RR00080

ACRONYM: RR

MEDLINETA: Psychiatry Res

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