Neuroendocrine differentiation in prostate cancer.

Neuroendocrine differentiation in prostate cancer. Research Abstract Details 

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Neuroendocrine differentiation in prostate cancer. Abstract Text:

Snezana J Cerovi?,Goran R Brajuskovi?,Vinka D Vukoti? Maleti?,Sava R Mi?i?,

BACKGROUND: In numerous recent studies attention has been focused to neuroendocrine differentiation (NED) in prostate cancer (PC). Focal NED is present in almost all PCs, but it is prominent in only 5-10% of the carcinomas. The prognostic significance of focal NED in PC is controversial, but current evidence suggests its influence on the onset and/or conversion of hormone resistant tumor phenotype. The aim of this study was to evaluate the relationship between NED status, based only on immunohistochemical use of neuroendocrine (NE) markers, with PC grade and stage, and preoperative serum levels of prostate-specific antigen (PSA). METHODS: The study included the biopsy material of 73 untreated PC patients (pts.) obtained by transurethral resection (TUR) (37 pts.), and radical retropubic prostatectomy (RRP) (36 pts.). Two representative tissue samples (typically the block containing the largest amount of neoplasm) were selected for immunohistochemical (IMM) staining. NE cells were identified using a panel of IMM markers: chromogranin A, neuron-specific enolase, and serotonin. The level of PC exocrine differentiation was detected by monoclonal antibodies against PSA. RESULTS: Significant expression of NE cells was demonstrated in 26 (70.2%) pts. with PC after TUR. In this group, serum preoperative PSA values ranged from 0.1 to 9.6 ng/ml. The majority of pts. with NED had low differentiated PC with Gleason grade score (GGS) > 7, and normal PSA values below 4 ng/ml (77%), in clinical stage D (54%). Statistically significant correlation (p<0.01) of positive NED with higher stage and grade and low PSA values was established. Among the pts. with localized PC in whom RRP was performed (n=36), significant expression of NE cells was found in 15 pts. (41.7%), 8 (53.3%) in pT2 stage, and 7 (46.7%) in pT3 stage. Significant correlation between NED with preoperative PSA values and stage of PC in pts. with RRP was not found. CONCLUSION: We demonstrated the significant NED in poorly differentiated PC in patients in the advanced stage of the disease. The expression of NED in organ-confined PC did not correlate with tumor stage, but it correlated with tumor grade (GGS < or = 7).

Neuroendocrine differentiation in prostate cancer. Publishing Authors By Initials

SJ Cerovi?,GR Brajuskovi?,VD Vukoti? Maleti?,SR Mi?i?,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

PUBMED ID PMID:

MEDLINE DATE: 2004 Sep-Oct

Neuroendocrine differentiation in prostate cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vojnosanitetski pregled. Military-medical and phar

VOLUME: 61

Page Numbers: 513-8

Journal Abbreviation:

ISSN: 0042-8450

DAY: 9

MONTH: 01

YEAR: 2008

Neuroendocrine differentiation in prostate cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 21530700

Neuroendocrine differentiation in prostate cancer. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: analysis

Chemical & Substance for Abstract: Neuroendocrine differentiation in prostate cancer. Information

Substance Name: Phosphopyruvate Hydratase

Registry Number: EC 4.2.1.11

Grant and Affiliation Information for Neuroendocrine differentiation in prostate cancer.

AFFILIATION: Military Medical Academy, Institute of Pathology, Belgrade, Serbia & Montenegro.

Country: Yugoslavia

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MEDLINETA: Vojnosanit Pregl

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