Neurodevelopmental changes of fetal pain.

Neurodevelopmental changes of fetal pain. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Neurodevelopmental changes of fetal pain. Abstract Text:

Curtis L Lowery,Mary P Hardman,Nirvana Manning,R Whit Hall,K J S Anand,Curtis L Lowery,Mary P Hardman,Nirvana Manning,R Whit Hall,K J S Anand,

Pain in the developing fetus is controversial because of the difficulty in measuring and interpreting pain during gestation. It has received increased attention lately because of recently introduced legislation that would require consideration of fetal pain during intentional termination of pregnancy. During development, sensory fibers are abundant by 20 weeks; a functional spinal reflex is present by 19 weeks; connections to the thalamus are present by 20 weeks; and connections to subplate neurons are present by 17 weeks with intensive differentiation by 25 weeks. These cells are important developmentally, but decline as a result of natural apoptosis. Mature thalamocortical projections are not present until 29 to 30 weeks, which has led many to believe the fetus does not experience emotional "pain" until then. Pain requires both nociception and emotional reaction or interpretation. Nociception causes physiologic stress, which in turn causes increases in catecholamines, cortisol, and other stress hormones. Physiological stress is different from the emotional pain felt by the more mature fetus or infant, and this stress is mitigated by pain medication such as opiates. The plasticity of the developing brain makes it vulnerable to the stressors that cause long-term developmental changes, ultimately leading to adverse neurological outcomes. Whereas evidence for conscious pain perception is indirect, evidence for the subconscious incorporation of pain into neurological development and plasticity is incontrovertible. Scientific data, not religious or political conviction, should guide the desperately needed research in this field. In the meantime, it seems prudent to avoid pain during gestation.

Neurodevelopmental changes of fetal pain. Publishing Authors By Initials

CL Lowery,MP Hardman,N Manning,RW Hall,KJ Anand,CL Lowery,MP Hardman,N Manning,RW Hall,KJ Anand,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Neurodevelopmental changes of fetal pain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Seminars in perinatology

VOLUME: 31

Page Numbers: 275-82

Journal Abbreviation: Semin. Perinatol.

ISSN: 0146-0005

DAY: 1

MONTH: Oct

YEAR: 2007

Neurodevelopmental changes of fetal pain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7801132

Neurodevelopmental changes of fetal pain. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Neurodevelopmental changes of fetal pain. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Neurodevelopmental changes of fetal pain.

AFFILIATION: Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. LoweryCurtisL@uams.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Semin Perinatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Neurodevelopmental changes of fetal pain Related Publications

• Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study.
• Anaesthetic neurotoxicity in rodents: is the ketamine controversy real?
• Applying the gender lens to abdominal aortic aneurysm screening.
• Comparison of epilenticular IOL implantation vs technique of anterior and primary posterior capsulorhexis with anterior vitrectomy in paediatric cataract surgery.
• Computer aided analysis of phonocardiogram.
• Current controversies regarding pain assessment in neonates.
• Effect of egg yolk lipids on the freezing of goat semen.
• Fears and beliefs of patients regarding cardiac catheterization.
• Giant villous adenoma presenting as a mass protruding from the rectum in a 29-year-old female patient.
• Impact of external haematology proficiency testing programme on quality of laboratories.
• Is too much neurohormonal blockade harmful?
• Isolated intraorbital metastasis in breast carcinoma.
• Labelled cleanable sheeting to facilitate microvascular clamp identification.
• Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database.
• Malaria parasite burden and treatment seeking behavior in ethnic communities of Assam, Northeastern India.
• Mechanisms of synergy between alcohol and hepatitis C virus.
• Microwave enhanced polarization in a carbon dioxide molecule.
• Neurobehavior of preterm infants at 36 weeks postconception as a function of morphine analgesia.
• Neurodevelopmental changes of fetal pain.
• Neuronal markers in allergic rhinitis: expression and correlation with sensory testing.
• Non-pharmacological techniques for pain management in neonates.
• Pain assessment in preterm neonates.
• Pharmacological approaches to the management of pain in the neonatal intensive care unit.
• Premedication for tracheal intubation in neonates: confusion or controversy?
• Seeing through the blind! Ability of hospital staff to differentiate morphine from placebo, in neonates at a placebo controlled trial.
• Sex and gender subgroup analyses of randomized trials the need to proceed with caution.
• Studies on sorption of Cd(II) on Tata chromite mine overburden.
• Voltage-gated ion channel Na(v)1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).
• Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies.
• Yoga in premature ejaculation: a comparative trial with fluoxetine.